Publication Date:
2002-09-21
Description:
Micro-RNAs (miRNAs) are regulatory molecules that mediate effects by interacting with messenger RNA (mRNA) targets. Here we show that Arabidopsis thaliana miRNA 39 (also known as miR171), a 21-ribonucleotide species that accumulates predominantly in inflorescence tissues, is produced from an intergenic region in chromosome III and functionally interacts with mRNA targets encoding several members of the Scarecrow-like (SCL) family of putative transcription factors. miRNA 39 is complementary to an internal region of three SCL mRNAs. The interaction results in specific cleavage of target mRNA within the region of complementarity, indicating that this class of miRNA functions like small interfering RNA associated with RNA silencing to guide sequence-specific cleavage in a developmentally controlled manner.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Llave, Cesar -- Xie, Zhixin -- Kasschau, Kristin D -- Carrington, James C -- AI27832/AI/NIAID NIH HHS/ -- AI43288/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):2053-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242443" target="_blank"〉PubMed〈/a〉
Keywords:
Arabidopsis/*genetics/metabolism
;
Arabidopsis Proteins/*genetics/metabolism
;
Base Pair Mismatch
;
Base Sequence
;
DNA, Intergenic
;
Gene Silencing
;
MicroRNAs
;
Plant Leaves/genetics/metabolism
;
Plant Stems/genetics/metabolism
;
Plant Structures/genetics/metabolism
;
RNA, Antisense/genetics/*metabolism
;
RNA, Messenger/genetics/*metabolism
;
RNA, Plant/genetics/metabolism
;
RNA, Small Interfering
;
RNA, Untranslated/genetics/*metabolism
;
Transcription Factors/*genetics/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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