Publication Date:
2011-01-08
Description:
The role of electrical synapses in synchronizing neuronal assemblies in the adult mammalian brain is well documented. However, their role in learning and memory processes remains unclear. By combining Pavlovian fear conditioning, activity-dependent immediate early gene expression, and in vivo electrophysiology, we discovered that blocking neuronal gap junctions within the dorsal hippocampus impaired context-dependent fear learning, memory, and extinction. Theta rhythms in freely moving rats were also disrupted. Our results show that gap junction-mediated neuronal transmission is a prominent feature underlying emotional memories.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276370/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276370/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bissiere, Stephanie -- Zelikowsky, Moriel -- Ponnusamy, Ravikumar -- Jacobs, Nathan S -- Blair, Hugh T -- Fanselow, Michael S -- P01 NS035985/NS/NINDS NIH HHS/ -- P01NS35985/NS/NINDS NIH HHS/ -- R01 MH062122/MH/NIMH NIH HHS/ -- R01 MH079511/MH/NIMH NIH HHS/ -- R01-MH079511/MH/NIMH NIH HHS/ -- R01-MH62122/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2011 Jan 7;331(6013):87-91. doi: 10.1126/science.1193785.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, University of California, Los Angeles, CA 90095, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21212357" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Carbenoxolone/pharmacology
;
Conditioning, Classical
;
Connexins/antagonists & inhibitors/metabolism
;
Electrical Synapses/drug effects/*physiology
;
Extinction, Psychological
;
*Fear
;
Gene Expression/drug effects
;
Genes, fos
;
Hippocampus/*physiology
;
*Learning
;
Male
;
Mefloquine/pharmacology
;
*Memory
;
Rats
;
Rats, Long-Evans
;
Theta Rhythm
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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