ISSN:
0009-2940
Keywords:
Chemistry
;
Inorganic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
The Synthesis of Secretin, II. Preparation of the Sequence 12-27The synthesis of L-arginyl(hydrobromide)-L-leucyl-L-arginyl(hydrobromide)-L-aspartyl(β-tert-butylester)-O-tert-butyl-L-seryl-L-alanyl-L-arginyl(hydrobromide)-L-leucyl-L-glutaminyl-L-arginyl(hydrobromide)-L-leucyl-L-glutaminyl-L-arginyl(hydrobromide)-L-leucyl-L-leucyl-L-glutaminyl-glycyl-L-leucyl-L-valinamide hydrobromide is described. This fully side-chain protected hexadecapeptideamide (fragment 12-27 of secretin) was prepared starting from the fragment 18-27, which was described earlier, and could easily be purified by gelfiltration on Sephadex in aqueous solutions due to the presence of four watersoluble arginine hydrobromide moieties.
Notes:
Die Synthese von L-Arginyl(hydrobromid)-L-leucyl-L-arginyl(hydrobromid)-L-asparagyl(β-tert.-butylester)-O-tert.-butyl-L-seryl-L-alanyl-L-arginyl(hydrobromid)-L-leucyl-L-glutaminyl-L-arginyl(hydrobromid)-L-leucyl-L-leucyl-L-glutaminyl-glycyl-L-leucyl-L-valin-amid-hydrobromid (= Fragment II) der amino-freien, sonst allseits geschützten Sequenz 12-27 des Sekretins, aufbauend auf der früher synthetisierten Sequenz 18-27, wird beschrieben.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/cber.19711040813
Permalink