ISSN:
1040-7685
Keywords:
cis-platinum determination
;
microcolumn liquid chromatography
;
β-cyclodextrin stationary phase
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A simple method for determining chemotherapeutically active cis-platinum using a β-cyclodextrin stationary phase on a silica gel carrier (β-CD-sil) is described. Retention of CDDP is considerably influenced by the content of acetonitrile in the mobile phase. With an electrochemical detector in oxidation mode, the minimal detectable amount of CDDP was determined to be 1.6 · 10-11 mol, and the minimal detectable concentration in the sample was 5 ppm (5 m̈g/mL). The method was used to determine CDDP concentration in the samples of body fluid (ascites).
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mcs.1220020507
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