ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Synthesis of Selectively N-Functionalized Polyamine DerivativesA threefold differently protected derivative 8 of the triamine spermidine (2) has been prepared in three steps starting from propane-1,3-diamine (1). The protected spermidine derivative 8 was converted to its spermine analogue 12, a useful polyamine intermediate. In a convergent way, the fourfold differently protected derivative 18 of the tetraamine spermine (3) has been obtained by coupling the two different and separately prepared propane-1,3-diamine units 15 and 17. Spermidine derivative 19 and spermine derivative 20, both selectively protected at both primary amino groups, have been Prepared from the free polyamines 2 and 3, respectively, in a direct approach.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19930760412
Permalink
