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  • Chemistry  (5)
  • free thyroxine  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Measurement of free thyroid hormones in patients on long-term phenytoin therapy (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 633-634 
    Details
    ISSN: 1432-1041
    Keywords: phenytoin ; thyroid hormones ; thyroid function tests ; free thyroxine ; free triiodothyronine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Total thyroxine and triiodothyronine levels are often reduced in long-term phenytoin therapy, a finding at variance with the euthyroid clinical state of these subjects. We have measured free (biologically active) thyroid hormone levels in 31 patients on phenytoin therapy and have found a significant reduction in measurements of both free thyroxine and free triiodothyronine. In contrast, addition of phenytoin to normal serum in vitro resulted in an increase in free thyroxine and free triiodothyronine concentrations. The findings in vitro are consistent with displacement of thyroid hormones from thyroxine binding globulin while the reduced free hormone levels in vivo confirm that the effects of phenytoin are not confined to binding inhibition and suggest that phenytoin has induced a change in the cellular metabolism of thyroid hormones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543499
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  • 2
    Electronic Resource
    Electronic Resource
    Mass spectrometric studies of thyroxine and related compounds. Trimethylsilyl derivatives (1974)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 1 (1974), S. 374-380 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of the trimethylsilyl derivatives of thyroxine and sixteen related compounds are reported. In addition to deiodinated analogues and iodinated tyrosines, the latter include a series of thyroacetic and thyropropionic acids and one thyroformic acid compound. Their spectra are discussed in terms of their fragmentation and utility for qualitative and quantitative estimation by gas chromatography - mass spectrometry.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200010603
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  • 3
    Electronic Resource
    Electronic Resource
    Absorption of water by proteins and related compoundsProd. No. 1376 (1966)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 10 (1966), S. 1191-1201 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Isotherms have been obtained for the absorption of water by proteins and polyamides and by simple amides closely related to the repeat chemical unit of the polymers. The differential heat of absorption of water at zero water content has also been determined for these substances, from isosteres and from heats of mixing. In addition the nature of the hydrogen bonding of water to these compounds has been investigated by infrared spectroscopic methods. The large differences found between the heats of absorption by the polymers and the simple model compounds are discussed.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1966.070100810
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  • 4
    Electronic Resource
    Electronic Resource
    Development of a gas chromatographic selected ion monitoring assay for thyroxine (T4) in human serum (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 421-427 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The components of a gas chromatographic mass spectrometric-selected ion monitoring (SIM) assay for thyroxine (T4) in human serum are described. The internal standard for the assay was synthesized from deuterium-labelled 3,5-diiodotyrosine and 3,5-diiodo-4-hydroxyphenylpyruvic acid. A novel method was developed for isolating the products of the coupling reaction. The results obtained by gas chromatography mass spectrometry SIM were compared with those of radioimmunoassay. The gas chromatographic mass spectrometric SIM assay would form the basis of a reference assay for T4.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200110811
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  • 5
    Electronic Resource
    Electronic Resource
    Mass spectral properties of volatile derivatives of thyronine (To) and use of these in the study of thyronine excretion in Eu-, Hyper- and hypothroidism (1984)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 11 (1984), S. 193-198 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectral properties of four classes of derivatives of thyronine are discussed (oxazolidinone, O-methyl oxazolidinone, O-acetyl oxazolidinone and N,O-diheptafluorobutyryl methyl ester). An assay for thyronine in human urine is described based on the N,O-diheptafluorobutyryl methyl ester. Results of To excretion in euthyroid humans were compared with those obtained previously using an assay based on the O-acetyl oxazolidinone derivative. Patients with frank hyperthyroidism had significantly higher To excretion than euthyroid subjects (2α 〈 0.002) and hypothyroid patients lower To excretions than enthyroid subjects (2α 〈 0.002). Some overlap between the two pathological ranges and the normal euthyroid range was evident.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200110411
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  • 6
    Electronic Resource
    Electronic Resource
    3,5-diiodotyrosine excretion in human urine in individuals of differing thyroidal status (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1983), S. 507-511 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The urinary excretion of 3,5-diiodotyrosine was determined in euthyroid, hypothyroid and hyperthyroid individuals using a sensitive gas chromatographic mass spectrometric assay. This involved a multi-step extraction of the amino acid from urine (mean efficiency 28±5.7%) then conversion to the N,O -diheptafluorobutyryl methyl ester. The fragmentation of the derivative is discussed. Although the mean excretions in the two pathological states were significantly different from that of euthyroid individuals (P〈0.01 in both instances) there was considerable overlap with the normal range.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200100906
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