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  • Chemistry  (5)
  • Large-Conductance Calcium-Activated Potassium Channel beta Subunits  (1)
  • 1
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    A molecular mechanism for electrical tuning of cochlear hair cells (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-01-08
    Description: Cochlear frequency selectivity in lower vertebrates arises in part from electrical tuning intrinsic to the sensory hair cells. The resonant frequency is determined largely by the gating kinetics of calcium-activated potassium (BK) channels encoded by the slo gene. Alternative splicing of slo from chick cochlea generated kinetically distinct BK channels. Combination with accessory beta subunits slowed the gating kinetics of alpha splice variants but preserved relative differences between them. In situ hybridization showed that the beta subunit is preferentially expressed by low-frequency (apical) hair cells in the avian cochlea. Interaction of beta with alpha splice variants could provide the kinetic range needed for electrical tuning of cochlear hair cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ramanathan, K -- Michael, T H -- Jiang, G J -- Hiel, H -- Fuchs, P A -- DC00276/DC/NIDCD NIH HHS/ -- New York, N.Y. -- Science. 1999 Jan 8;283(5399):215-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Hearing Sciences, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9880252" target="_blank"〉PubMed〈/a〉
    Keywords: Alternative Splicing ; Animals ; Calcium/metabolism ; Cell Line ; Electrophysiology ; Gene Expression ; Hair Cells, Auditory/*physiology ; Humans ; In Situ Hybridization ; *Ion Channel Gating ; Kinetics ; Large-Conductance Calcium-Activated Potassium Channel beta Subunits ; Large-Conductance Calcium-Activated Potassium Channels ; Membrane Potentials ; Patch-Clamp Techniques ; Potassium Channels/genetics/*physiology ; *Potassium Channels, Calcium-Activated ; Quail ; RNA, Messenger/genetics/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Mass spectrometric identification of polycycloaddition of arylchlorocarbenes and fluorenylidene to buckministerfullerene (1994)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 29 (1994), S. 391-393 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210290710
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  • 3
    Electronic Resource
    Electronic Resource
    Kinetics of the oxidation of cyclohexene by thallium(III) acetate (1985)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 17 (1985), S. 559-571 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The kinetics of the reaction by which thallium(III) acetate oxidizes cyclohexene in glacial acetic acid medium, has been studied by UV spectrophotometric observation at 30°C. The consumption of thallium(III) acetate follows a second-order rate law exhibiting first-order dependence on each of thallium(III) acetate and cyclohexene; however, the first-order dependence on cyclohexene disappears at high cyclohexene concentrations as pseudo-first-order conditions prevail above 0.2 M cyclohexene. A steady-state model of the following form is proposed: where Tl, Cy, and Com are units of Thallium(III) acetate, cyclohexene, and a reaction complex. The value of k2 has been evaluated as 0.00027 and (k-1 + k2) as 0.0385k1. For low thallium(III) acetate concentrations the reaction kinetics follow the rate law: \documentclass{article}\pagestyle{empty}\begin{document}$$ d[{\rm Tl}]/dt = - 0.00027([{\rm Tl}] + \alpha)[{\rm Tl}]/(0.0385 + 2[{\rm Tl}] + \alpha) $$\end{document} where α = the excess concentration of cyclohexene over thallium(III) triacetate. For thallium(III) acetate concentrations above 0.02 M, double salt formation of thallium(III) acetate with product thallium(I) acetate removes thallium(III) acetate from the reaction and a modified rate law is observed. Runge-Kutta numerical solutions to the differential equations provide confirmation that the rate expressions are valid in predicting the observed concentrations of thallium(III) acetate.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550170602
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  • 4
    Electronic Resource
    Electronic Resource
    Thermal decomposition of 3-chloro-3-trichloromethyldiazirine in solution (1972)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 4 (1972), S. 229-233 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The thermal decomposition of 3-chloro-3-trichloromethyldizairine in carbon tetrachloride and iso-octane has been investigated over the temperature range 75-115°C. The products, tetrachloroethylene and nitrogen, are formed quantitatively by a first-order reaction which is probably unimolecular: The results yielded the following Arrhenius equations: \documentclass{article}\pagestyle{empty}\begin{document}$$\begin{array}{l} k({\rm CCl}_{\rm 4} {\rm)} = {\rm 10}^{{\rm 13}{\rm .8} \pm {\rm 0}{\rm .2}} \exp (- 29,200 \pm 200/RT)\sec ^{ - 1} \\ k(iso - {\rm octane)} = {\rm 10}^{{\rm 13}{\rm .8} \pm {\rm 0}{\rm .2}} \exp (- 29,000 \pm 150/RT)\sec ^{ - 1} \\ \end{array}$$\end{document}.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550040209
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  • 5
    Electronic Resource
    Electronic Resource
    Pyrolysis of trifluoroacetaldehyde. The formation of trifluoromethane and hexafluoroethane (1977)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 9 (1977), S. 589-593 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The thermal decomposition of trifluoroacetaldehyde at temperatures f 471 to 519°C has been studied by measuring the rates of formation of CF3H and C2F6. It is concluded that the high-pressure reaction mechanism involves a Rice-Herzfeld reaction scheme with first-order initiation and second-order termination via CF3 combination. However, a falloff in reaction rates is observed at pressures below 100 mmHg. The Arrhenius parameters of the three rate constants corresponding to the overall reaction, the initiation reaction, and an abstraction reaction have been evaluated.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550090407
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  • 6
    Electronic Resource
    Electronic Resource
    Kinetics of the 1,5-dipolar cyclization of 2-Vinylpyridinium ylides to Indolizines. Determination of rate parameters by laser flash photolysis (1994)
    New York, NY : Wiley-Blackwell
    International Journal of Chemical Kinetics 26 (1994), S. 1179-1184 
    Details
    ISSN: 0538-8066
    Keywords: Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Nanosecond laser flash photolysis (λ = 355 nm) of an aqueous solution of 3-chloro-3-p-chlorophenyldiazirine in isooctane produces a transient absorption at 310 nm due to the formation of the carbene. In the presence of 2-vinylpyridine, a second transient with a broad absorption band peaking at 520 nm grows in. This absorption is attributed to 2-vinylpyridinium ylide. The ylide decays with a lifetime equal to 33 µs at 25°C independent of the concentration of 2-vinylpyridine. As the ylide decays, there is a concomitant growth of an absorption at 330 nm, attributed to the formation of inodolizine. The activation parameters for the 1,5-dipolar cyclization of the ylide to indolizine were determined; Ea = 12.1 kcal mol-1 and log A = 13.4. © 1994 John Wiley & Sons, Inc.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/kin.550261205
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