ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Plasma concentrations and urinary excretion of the antiarrhythmic quaternary ammonium compound QX-572 in man (1975)

Rydén, L. ; Berlin, A. ; Treiber, L. R.

Springer

European journal of clinical pharmacology 8 (1975), S. 277-282

add to mindlist on the mindlist

Details

ISSN: 1432-1041

Keywords: QX-572 ; quaternary ammonium compound ; plasma level ; urinary excretion ; man ; anti-arrhythmic drug

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary A quantitative thin layer chromatographic (TLC) method has been developed for determination of the antiarrhythmic quaternary ammonium compound N, N-bis (phenylcarbamoylmethyl) dimethylammonium chloride (QX-572) in biological materials. Prior to chromatography QX-572 was transferred into chloroform as perchlorate by ion pair extraction. Tritium-labelled QX-572 was used as the internal standard and a TLC scanning spectrophotometer equipped with a linear detector system afforded the required accuracy, specificity and simplicity. The method was used to determine QX-572 in plasma from 11 patients with various cardiac diseases who received QX-572 8 mg/kg body wt. as an intravenous infusion over 30 min. There was a rapid initial decay of the plasma levels from 11.0±1.1 µg/ml (mean ± SE) at the end of infusion to 3.5±0.5 µg/ml after 30 min. 240 min after commencement of the infusion the plasma level was 0.7±0.1 µg/ml. In these patients 22±2% (mean±SE) of the total administered dose of QX-572 was excreted unchanged in urine during the 24 hours following infusion of the drug. A second group of 28 patients with acute myocardial infarction also received QX-572 8 mg/kg body wt. Their plasma levels did not differ significantly from those found in the first group of patients. There was a poor correlation between the amount of QX-572 administered and plasma level at the end of the infusion. The study has provided some preliminary data about the pharmacokinetics of QX-572, but before a detailed analysis can be done data from longer periods of observation is required. The present results suggest that in future QX-572 can be administered in a standardized dosage, what would be advantageous in practice.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00567128

Permalink

	Location	Call Number	Expected	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Polymers with conjugated bonds in the macromolecular chains (1963)

Berlin, A. A. ; Popova, Z. V. ; Yanovskii, D. M.

Stamford, Conn. [u.a.] : Wiley-Blackwell

Polymer Engineering and Science 3 (1963), S. 27-31

add to mindlist on the mindlist

Details

ISSN: 0032-3888

Keywords: Chemistry ; Chemical Engineering

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics

Notes: The effect of polymers with conjugated bonds, namely polyphenylvinylene, phenylacetylenep-diethinylbenzene copolymer and thermally dehydrochlorinated polyvinylchloride, upon the stability of polyvinylchloride suspensions has been investigated. It has been shown that polymers with conjugated double bonds are efficient inhibitors of the thermal dehydrochlorination of polyvinylchloride. The most active inhibitor, polyphenylvinylene, is not light stabilized.

Additional Material: 2 Ill.