Publication Date:
2009-06-27
Description:
Stem cell fate is influenced by a number of factors and interactions that require robust control for safe and effective regeneration of functional tissue. Coordinated interactions with soluble factors, other cells, and extracellular matrices define a local biochemical and mechanical niche with complex and dynamic regulation that stem cells sense. Decellularized tissue matrices and synthetic polymer niches are being used in the clinic, and they are also beginning to clarify fundamental aspects of how stem cells contribute to homeostasis and repair, for example, at sites of fibrosis. Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847855/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847855/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Discher, Dennis E -- Mooney, David J -- Zandstra, Peter W -- R37 DE013033/DE/NIDCR NIH HHS/ -- R37 DE013033-12/DE/NIDCR NIH HHS/ -- New York, N.Y. -- Science. 2009 Jun 26;324(5935):1673-7. doi: 10.1126/science.1171643.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Biophysical Engineering and Nanobiopolymers Laboratory, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA. discher@seas.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19556500" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cell Adhesion
;
Cell Differentiation
;
Cell Proliferation
;
Cell Survival
;
Extracellular Matrix/*physiology
;
Fibrosis
;
Humans
;
Intercellular Signaling Peptides and Proteins/*metabolism/pharmacology
;
Stem Cell Niche/*physiology
;
Stem Cell Transplantation
;
Stem Cells/*cytology/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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