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  • Cell Biology, Medicine, Diseases  (1)
  • Key words Ectomycorrhizae  (1)
  • Phosphorus  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Mycorrhiza 3 (1993), S. 97-106 
    ISSN: 1432-1890
    Keywords: Soil transfer ; Reforestation ; Populus ; Phosphorus ; Boreal forest
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Soil transfers, presumed to contain mycorrhizal fungal inoculum from a native plant community, were applied to rooted cuttings and volunteer plants of Populus balsamifera L. to improve their growth on an abandoned mined site in south central Alaska. The objectives of the study were to determine (1) if these soil transfers could be substituted for additional P fertilizer when applied with a base level of NP fertilizer to improve growth, and (2) if P added to treatments receiving a base level of NP fertilizer and soil transfer would suppress mycorrhizal formation. Physical dimensions of plants were measured near the beginning and end of each of two growing seasons. Several plants per plot were harvested at the end of year 2 to determine mycorrhizal formation, current growth, and leaf nutrient concentrations. Plant height was significantly increased only when soil transfer and additional P treatments were combined. Response to additions of P fertilization alone or soil transfer alone were not significantly different from each other. Current twig growth increased with either treatment alone or both combined. Soil transfer on cuttings resulted in more ectomycorrhizal formation than either the control or additional P. Leaf N concentrations on cuttings and volunteers increased when plants were treated with soil transfer. Similar growth responses were achieved by soil transfers or additional P, but mycorrhizal formation was improved with the soil transfer treatments. P added to the base level plus soil transfer did not suppress or improve mycorrhizal formation compared to that with soil transfer alone.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1890
    Keywords: Key words Ectomycorrhizae ; Glacier ; Succession ; Chronosequence ; Alnus ; Populus ; Picea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Ectomycorrhiza (EM) formation on plant roots in successional communities may vary with plant species, plant age, and age of vegetation after disturbance. To evaluate differences in mycorrhizal fungus communities on roots of same-aged seedlings across a deglaciated chronosequence, indoor-grown bioassay plants of four dominant species Epilobium latifolium L. (dwarf fireweed), Populus balsamifera ssp. trichocarpa (Torr.&Gray) Hult. (black cottonwood), Alnus sinuata (Regel) Rydb. (Sitka alder), and Picea sitchensis (Bong.) Carr. (Sitka spruce) were transplanted into five successional stages (Barren, Isolated Plant, Patchy, Alder, and Cottonwood) following deglaciation near Exit Glacier, Alaska. The species were selected for their successional status and mycorrhiza formation potential [EM or arbuscular mycorrhiza (AM) or both]. Seedlings were transplanted in June 1992, and half were harvested at the ends of the two subsequent growing seasons. The EM communities on P. balsamifera differed across the chronosequence while those of the other species did not. Morphotype B dominated the EM on P. balsamifera after the Barren stage, and the greatest EM colonization was in the Isolated Plant and Patchy stages. No AM were found. The EM observed on even-aged seedlings in this study were a subset of the EM found on naturally occurring plants (seedlings to mature trees) in a prior study, and some were common to multiple plant species. Most plant growth responses were not significant across stages or were inconsistent among plant species.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2017-12-01
    Description: Kinase inhibitors are important cancer therapeutics. Polypharmacology is commonly observed, requiring thorough target deconvolution to understand drug mechanism of action. Using chemical proteomics, we analyzed the target spectrum of 243 clinically evaluated kinase drugs. The data revealed previously unknown targets for established drugs, offered a perspective on the "druggable" kinome, highlighted (non)kinase off-targets, and suggested potential therapeutic applications. Integration of phosphoproteomic data refined drug-affected pathways, identified response markers, and strengthened rationale for combination treatments. We exemplify translational value by discovering SIK2 (salt-inducible kinase 2) inhibitors that modulate cytokine production in primary cells, by identifying drugs against the lung cancer survival marker MELK (maternal embryonic leucine zipper kinase), and by repurposing cabozantinib to treat FLT3-ITD–positive acute myeloid leukemia. This resource, available via the ProteomicsDB database, should facilitate basic, clinical, and drug discovery research and aid clinical decision-making.
    Keywords: Cell Biology, Medicine, Diseases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
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