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  • Cell & Developmental Biology  (1)
  • Leydig tumor cells  (1)
  • 1
    Electronic Resource
    Electronic Resource
    A transformed murine Leydig cell line expresses the ETA receptor subtype (1994)
    Springer
    Molecular and cellular biochemistry 136 (1994), S. 91-96 
    Details
    ISSN: 1573-4919
    Keywords: endothelin-1 ; endothelin receptor ; Leydig tumor cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract We recently demonstrated that transformed murine Leydig cells (MA-10) responded to endothelin-1 (ET-1) via increased steroidogenesis. This study addresses the endothelin receptor subtype present on this cell line and whether or not the cells produce ET-1. The expression of the preproendothelin-1 (PPET-1) gene was investigated by Northern blot analysis, and PPET-1 mRNA was found to be 〈0.2% of that present in pulmonary endothelial cells. The medium from MA-10 cells, maintained under serum-free conditions, was analyzed by radio-immunoassay to determine immunoreactive-ET-1 production and ET-1 levels were found to be below the sensitivity of the assay (〈10 pg/ml). The data from competitive binding experiments with [125I]ET-1 and unlabeled ET-1, ET-3 and receptor subtype selective ligands yielded a single class of high affinity binding sites with ETA receptor subtype characteristics. The results of this study demonstrate that MA-10 cells possess the ETA receptor subtype but do not produce significant quantities of ET-1 under basal conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931610
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  • 2
    Electronic Resource
    Electronic Resource
    Human choriogonadotropin (1986)
    New York, NY : Wiley-Blackwell
    BioEssays 4 (1986), S. 70-75 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Human choriogonadotropin, a hormone derived from the syncytiotrophoblast cells of the placenta, is a member of the glycoprotein hormone family which also contains the pituitary hormones lutropin, follitropin and thyrotropin. These four hormones are comprised of two dissimilar subunits, one (α) being common to all four and the other (β) conferring hormonal specificity. Information is rapidly accumulating on the nature and regulation of the genes for these subunits, as well as the structural aspects, mechanism-of-action and physiological roles of these complex hormones. This mini review considers some of the recent advances in our understanding of human choriogonadotropin.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950040207
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