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  • 1
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    Sensitivity of intermediate mass fragment flows to the symmetry energy (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-06-08
    Description: Author(s): Z. Kohley, M. Colonna, A. Bonasera, L. W. May, S. Wuenschel, M. Di Toro, S. Galanopoulos, K. Hagel, M. Mehlman, W. B. Smith, G. A. Souliotis, S. N. Soisson, B. C. Stein, R. Tripathi, S. J. Yennello, and M. Zielinska-Pfabe The NIMROD-ISiS array was used to study the transverse flow of intermediate mass fragments in 35 MeV/nucleon 70 Zn+ 70 Zn , 64 Zn+ 64 Zn , and 64 Ni+ 64 Ni reactions. The intermediate mass fragment flow was previously shown to be sensitive to the density dependence of the symmetry energy. To explore the model ... [Phys. Rev. C 85, 064605] Published Thu Jun 07, 2012
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 2
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    Transverse collective flow and midrapidity emission of isotopically identified light charged particles (2011)
    American Physical Society (APS)
    Details
    Publication Date: 2011-04-02
    Description: Author(s): Z. Kohley, L. W. May, S. Wuenschel, M. Colonna, M. Di Toro, M. Zielinska-Pfabe, K. Hagel, R. Tripathi, A. Bonasera, G. A. Souliotis, D. V. Shetty, S. Galanopoulos, M. Mehlman, W. B. Smith, S. N. Soisson, B. C. Stein, and S. J. Yennello The transverse flow and relative midrapidity yield of isotopically identified light charged particles (LCPs) has been examined for the 35 MeV/nucleon ^{70} Zn+^{70} Zn, ^{64} Zn+^{64} Zn, and ^{64} Ni+^{64} Ni systems. A large enhancement of the midrapidity yield of the LCPs was observed relative to... [Phys. Rev. C 83, 044601] Published Fri Apr 01, 2011
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 3
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    Constraining the symmetry term in the nuclear equation of state at subsaturation densities and finite temperatures (2012)
    American Physical Society (APS)
    Details
    Publication Date: 2012-03-31
    Description: Author(s): P. Marini, A. Bonasera, A. McIntosh, R. Tripathi, S. Galanopoulos, K. Hagel, L. Heilborn, Z. Kohley, L. W. May, M. Mehlman, S. N. Soisson, G. A. Souliotis, D. V. Shetty, W. B. Smith, B. C. Stein, S. Wuenschel, and S. J. Yennello Methods of extraction of the symmetry energy (or enthalpy) coefficient to temperature ratio from isobaric and isotopic yields of fragments produced in Fermi-energy heavy-ion collisions are discussed. We show that the methods are consistent when the hot fragmenting source is well characterized and it... [Phys. Rev. C 85, 034617] Published Fri Mar 30, 2012
    Keywords: Nuclear Reactions
    Print ISSN: 0556-2813
    Electronic ISSN: 1089-490X
    Topics: Physics
    Published by American Physical Society (APS)
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  • 4
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    Selective inhibition of BET bromodomains (2010)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2010-09-28
    Description: Epigenetic proteins are intently pursued targets in ligand discovery. So far, successful efforts have been limited to chromatin modifying enzymes, or so-called epigenetic 'writers' and 'erasers'. Potent inhibitors of histone binding modules have not yet been described. Here we report a cell-permeable small molecule (JQ1) that binds competitively to acetyl-lysine recognition motifs, or bromodomains. High potency and specificity towards a subset of human bromodomains is explained by co-crystal structures with bromodomain and extra-terminal (BET) family member BRD4, revealing excellent shape complementarity with the acetyl-lysine binding cavity. Recurrent translocation of BRD4 is observed in a genetically-defined, incurable subtype of human squamous carcinoma. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models. These data establish proof-of-concept for targeting protein-protein interactions of epigenetic 'readers', and provide a versatile chemical scaffold for the development of chemical probes more broadly throughout the bromodomain family.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010259/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3010259/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Filippakopoulos, Panagis -- Qi, Jun -- Picaud, Sarah -- Shen, Yao -- Smith, William B -- Fedorov, Oleg -- Morse, Elizabeth M -- Keates, Tracey -- Hickman, Tyler T -- Felletar, Ildiko -- Philpott, Martin -- Munro, Shonagh -- McKeown, Michael R -- Wang, Yuchuan -- Christie, Amanda L -- West, Nathan -- Cameron, Michael J -- Schwartz, Brian -- Heightman, Tom D -- La Thangue, Nicholas -- French, Christopher A -- Wiest, Olaf -- Kung, Andrew L -- Knapp, Stefan -- Bradner, James E -- 13058/Cancer Research UK/United Kingdom -- G0500905/Medical Research Council/United Kingdom -- G1000807/Medical Research Council/United Kingdom -- G9400953/Medical Research Council/United Kingdom -- K08 CA128972/CA/NCI NIH HHS/ -- K08 CA128972-03/CA/NCI NIH HHS/ -- T32-075762/PHS HHS/ -- Canadian Institutes of Health Research/Canada -- Wellcome Trust/United Kingdom -- England -- Nature. 2010 Dec 23;468(7327):1067-73. doi: 10.1038/nature09504. Epub 2010 Sep 24.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Clinical Medicine, Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford OX3 7DQ, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20871596" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Azirines/chemical synthesis/chemistry/*pharmacology ; Binding Sites ; Carcinoma, Squamous Cell/physiopathology ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Chromatin/metabolism ; Dihydropyridines/chemical synthesis/chemistry/*pharmacology ; Female ; Humans ; Mice ; Mice, Nude ; *Models, Molecular ; Molecular Sequence Data ; Nuclear Proteins/*antagonists & inhibitors/*metabolism ; Protein Binding/drug effects ; Protein Structure, Tertiary ; Recombinant Proteins/metabolism ; Sequence Alignment ; Skin Neoplasms/physiopathology ; Stereoisomerism ; Transcription Factors/*antagonists & inhibitors/*metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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