ISSN:
1432-1041
Keywords:
Key words Neonates
;
CYP3A
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: Urinary 6β-hydroxycortisol/cortisol (6β-OHF/C) ratio was measured in human neonates to assess the CYP3A enzyme activity. Methods: Urinary 6β-OHF/C ratio was determined on the day of birth in 94 neonates including those born prematurely. In addition, changes in the ratios after birth were also determined in 81 neonates. Results: On the day of birth, a significant positive correlation was found between urinary 6β-OHF/C ratios and gestational age (r=0.476) and birth weight (r=0.283). There was no gender difference in the urinary 6β-OHF/C ratios in human neonates. Furthermore, delivery modes such as cesarean section and vaginal delivery did not appear to affect the urinary 6β-OHF/C ratio. The mean ratio of urinary 6β-OHF/C observed in 39 mature neonates (more than 37 weeks of gestational age) was higher than that observed in adults (16.5 vs 9.9). Within 5 days after birth, the ratio rapidly decreased to less than that in adults. In contrast, the mean ratio of urinary 6β-OHF/C observed in 42 premature neonates (under 37 weeks of gestational age) was significantly lower than that observed in mature neonates (5.3 vs 16.5) and was virtually unchanged during the 14-days after birth. Therefore, no significant difference was observed in the mean ratio of urinary 6β-OHF/C between mature and premature neonates at 5 days after birth. Conclusion: From these results, it was concluded that on the day of birth, mature neonates might possess a higher activity of CYP3A enzyme compared with premature neonates, and that the CYP3A enzyme activity in mature neonates might be promptly changed at an early stage after birth.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050390
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