ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • COMBINE  (1)
  • Race and ethnicity in the United States Census  (1)
  • 1
    ISSN: 1573-4951
    Keywords: AUTODOCK ; COMBINE ; cooked food heterocyclic amines ; cytochrome P450 1A2 ; docking simulation ; GRID/GOLPE ; 3D-QSAR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Many heterocyclic amines (HCA) present in cooked food exert a genotoxic activity when they are metabolised (N-oxidated) by the human cytochrome P450 1A2 (CYP1A2h). In order to rationalize the observed differences in activity of this enzyme on a series of 12 HCA, 3D-QSAR methods were applied on the basis of models of HCA–CYP1A2h complexes. The CYP1A2h enzyme model has been previously reported and was built by homology modeling based on cytochrome P450 BM3. The complexes were automatically generated applying the AUTODOCK software and refined using AMBER. A COMBINE analysis on the complexes identified the most important enzyme–ligand interactions that account for the differences in activity within the series. A GRID/GOLPE analysis was then performed on just the ligands, in the conformations and orientations found in the modeled complexes. The results from both methods were concordant and confirmed the advantages of incorporating structural information from series of ligand–receptor complexes into 3D-QSAR methodologies.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2024-03-29
    Description: In the last several years, much has been written about growing economic challenges, increasing income inequality, and political polarization in the United States. Addressing these new realities in America’s metropolitan regions, this book argues that a few lessons are emerging: first, inequity is bad for economic growth; second, bringing together the concerns of equity and growth requires concerted local action; and third, the fundamental building block for doing this is the creation of diverse and dynamic epistemic (or knowledge) communities, which help to overcome political polarization and to address the challenges of economic restructuring and social divides.
    Keywords: regional planning ; economic development ; cities and towns - united states ; income distribution ; economic policy ; urban development ; Race and ethnicity in the United States Census ; San Antonio ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBL Sociology: work and labour ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCM Development economics and emerging economies ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCS Economic systems and structures
    Language: English
    Format: image/jpeg
    Format: image/jpeg
    Format: image/jpeg
    Format: image/jpeg
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...