Publication Date:
2014-08-30
Description:
The pathogen recognition theory dictates that, upon viral infection, the innate immune system first detects microbial products and then responds by providing instructions to adaptive CD8 T cells. Here, we show in mice that tissue resident memory CD8 T cells (T(RM) cells), non-recirculating cells located at common sites of infection, can achieve near-sterilizing immunity against viral infections by reversing this flow of information. Upon antigen resensitization within the mouse female reproductive mucosae, CD8(+) T(RM) cells secrete cytokines that trigger rapid adaptive and innate immune responses, including local humoral responses, maturation of local dendritic cells, and activation of natural killer cells. This provided near-sterilizing immunity against an antigenically unrelated viral infection. Thus, CD8(+) T(RM) cells rapidly trigger an antiviral state by amplifying receptor-derived signals from previously encountered pathogens.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449618/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4449618/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schenkel, Jason M -- Fraser, Kathryn A -- Beura, Lalit K -- Pauken, Kristen E -- Vezys, Vaiva -- Masopust, David -- DP2 OD006467/OD/NIH HHS/ -- DP2-OD-006467/OD/NIH HHS/ -- F30 DK100159/DK/NIDDK NIH HHS/ -- F30DK100159/DK/NIDDK NIH HHS/ -- R01 AI084913/AI/NIAID NIH HHS/ -- R01AI084913/AI/NIAID NIH HHS/ -- T32 AI007313/AI/NIAID NIH HHS/ -- T32AI007313/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2014 Oct 3;346(6205):98-101. doi: 10.1126/science.1254536. Epub 2014 Aug 28.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. ; Department of Microbiology and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Microbiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. masopust@umn.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25170049" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptive Immunity/*immunology
;
Animals
;
Antigens, Viral/immunology
;
CD8-Positive T-Lymphocytes/*immunology
;
Female
;
Immunity, Humoral/immunology
;
Immunity, Innate/*immunology
;
*Immunologic Memory
;
Interferon-gamma/immunology
;
Mice
;
Mice, Inbred C57BL
;
Mucous Membrane/immunology/virology
;
Vascular Cell Adhesion Molecule-1/immunology
;
Virus Diseases/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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