ALBERT

All Library Books, journals and Electronic Records Telegrafenberg

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1573-4951
    Keywords: AUTODOCK ; COMBINE ; cooked food heterocyclic amines ; cytochrome P450 1A2 ; docking simulation ; GRID/GOLPE ; 3D-QSAR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Many heterocyclic amines (HCA) present in cooked food exert a genotoxic activity when they are metabolised (N-oxidated) by the human cytochrome P450 1A2 (CYP1A2h). In order to rationalize the observed differences in activity of this enzyme on a series of 12 HCA, 3D-QSAR methods were applied on the basis of models of HCA–CYP1A2h complexes. The CYP1A2h enzyme model has been previously reported and was built by homology modeling based on cytochrome P450 BM3. The complexes were automatically generated applying the AUTODOCK software and refined using AMBER. A COMBINE analysis on the complexes identified the most important enzyme–ligand interactions that account for the differences in activity within the series. A GRID/GOLPE analysis was then performed on just the ligands, in the conformations and orientations found in the modeled complexes. The results from both methods were concordant and confirmed the advantages of incorporating structural information from series of ligand–receptor complexes into 3D-QSAR methodologies.
    Type of Medium: Electronic Resource
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
  • 2
    facet.materialart.
    Unknown
    University of California Press | University of California Press
    Publication Date: 2023-02-02
    Description: In the last several years, much has been written about growing economic challenges, increasing income inequality, and political polarization in the United States. Addressing these new realities in America’s metropolitan regions, this book argues that a few lessons are emerging: first, inequity is bad for economic growth; second, bringing together the concerns of equity and growth requires concerted local action; and third, the fundamental building block for doing this is the creation of diverse and dynamic epistemic (or knowledge) communities, which help to overcome political polarization and to address the challenges of economic restructuring and social divides. “As America bolts toward a more multiracial future in the face of skyrocketing inequality, local leaders are desperately seeking strategies to foster more inclusive growth. Chris Benner and Manuel Pastor’s research uncovers a critical ingredient of success: diverse regional leaders coming together to build a foundation of shared knowledge and advance positive change.” — ANGELA GLOVER BLACKWELL, Founder and CEO, PolicyLink CHRIS BENNER is the Dorothy E. Everett Chair in Global Information and Social Entrepreneurship, Director of the Everett Program for Digital Tools for Social Innovation, and Professor of Environmental Studies and Sociology at the University of California, Santa Cruz. His most recent book, coauthored with Manuel Pastor, is Just Growth: Inclusion and Prosperity in America’s Metropolitan Region. His other books include This Could Be the Start of Something Big: How Social Movements for Regional Equity Are Transforming Metropolitan America and Work in the New Economy: Flexible Labor Markets in the New Economy. MANUEL PASTOR is Professor of Sociology and American Studies and Ethnicity at the University of Southern California, where he also serves as Director of USC’s Program for Environmental and Regional Equity (PERE) and Codirector of USC’s Center for the Study of Immigrant Integration (CSII). He is the coauthor of Uncommon Common Ground: Race and America’s Future and This Could Be the Start of Something Big: How Social Movements for Regional Equity Are Transforming Metropolitan America.
    Keywords: Political Science ; Political Economy ; Business & Economics ; Economics ; General ; Social Science ; General ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general
    Language: English
    Format: image/png
    Format: image/png
    Location Call Number Expected Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...