Publication Date:
1987-05-15
Description:
The murine epidermis contains a subpopulation of bone marrow-derived lymphocytes that have a dendritic morphology and that express Thy-1 and T3 cell-surface antigens but not other markers (L3T4 or Lyt-2) characteristic of mature peripheral T lymphocytes. An alternative type of T cell receptor was earlier identified on a subpopulation of murine thymocytes with a similar phenotype (T3+, L3T4-, Lyt-2-), but not on peripheral murine T lymphocytes. Two independently derived Thy-1+, L3T4-, and Lyt-2- dendritic cell lines of epidermal origin that express a T3-associated disulfide-linked heterodimer composed of a 34-kilodalton gamma-chain and 46-kilodalton partner (the delta chain) have now been identified. Analysis of N-linked glycosylation revealed that this receptor is similar to that detected on thymocytes. These results demonstrate that Thy-1+ dendritic epidermal cell lines can express gamma delta T cell receptors in vitro and suggest that Thy-1+ dendritic epidermal cells express such receptors in vivo. The localization of these gamma delta T cell receptor-expressing cells in the epidermis may be of importance for understanding the function of these receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Koning, F -- Stingl, G -- Yokoyama, W M -- Yamada, H -- Maloy, W L -- Tschachler, E -- Shevach, E M -- Coligan, J E -- F32AM07219-03/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1987 May 15;236(4803):834-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2883729" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, Surface/*analysis
;
Antigens, Thy-1
;
Bone Marrow/immunology
;
Cell Line
;
Mice
;
Molecular Weight
;
Receptors, Antigen, T-Cell/*analysis
;
T-Lymphocytes/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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