ISSN:
1432-1041
Keywords:
Beta-blockade
;
penbutolol
;
practolol
;
exercise-test
;
angina pectoris
;
side effects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The effect of penbutolol (Hoe 893 d), a new non-cardioselective beta-blocking agent presumed to have a prolonged action, was compared with practolol and placebo by exercise tests in 12 male patients with stable angina pectoris. The patients received oral penbutolol 20 mg, practolol 200 mg or placebo in a randomized, double blind, cross-over trial. The preparations used were in identical-appearing capsules — of penbutolol 10 mg, practolol 100 mg and placebo. Exercise tests were performed after 2 and 24 h. In the tests performed after 2 h, both beta-blockers increased the total work performed and the duration of work significantly more than placebo (p〈0.05). Penbutolol increased the exercise period before appearance of angina pectoris from 4.6 to 7.1 min (p〈0.05). The difference between practolol and placebo was not significant. The rate pressure product was significantly reduced after penbutolol compared to placebo (p〈0.05). At the amount of work that forced patients on placebo to stop, the ST-depression in the ECG was significantly reduced after beta-blocker (p〈0.05). However, at maximum work load no significant difference between the beta-blockers and placebo was found. After 24 h virtually no clinical effects were observed after either penbutolol or practolol. One patient on practolol complained of Raynaud's syndrome. No side effects were noted after penbutolol.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00609977
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