Publication Date:
1998-02-28
Description:
Although in Saccharomyces cerevisiae the initiation of meiotic recombination, as indicated by double-strand break formation, appears to be functionally linked to the initiation of synapsis, meiotic chromosome synapsis in Drosophila females occurs in the absence of meiotic exchange. Electron microscopy of oocytes from females homozygous for either of two meiotic mutants (mei-W68 and mei-P22), which eliminate both meiotic crossing over and gene conversion, revealed normal synaptonemal complex formation. Thus, synapsis in Drosophila is independent of meiotic recombination, consistent with a model in which synapsis is required for the initiation of meiotic recombination. Furthermore, the basic processes of early meiosis may have different functional or temporal relations, or both, in yeast and Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉McKim, K S -- Green-Marroquin, B L -- Sekelsky, J J -- Chin, G -- Steinberg, C -- Khodosh, R -- Hawley, R S -- New York, N.Y. -- Science. 1998 Feb 6;279(5352):876-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9452390" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Chromosomes/genetics/*physiology/ultrastructure
;
Crossing Over, Genetic
;
Drosophila melanogaster/genetics/*physiology
;
Female
;
Gene Conversion
;
*Meiosis
;
Mutation
;
Oocytes/physiology
;
*Recombination, Genetic
;
Saccharomyces cerevisiae/genetics/physiology
;
Sister Chromatid Exchange
;
Synaptonemal Complex/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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