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  • 1
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    The transcriptional program of sporulation in budding yeast (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-10-23
    Description: Diploid cells of budding yeast produce haploid cells through the developmental program of sporulation, which consists of meiosis and spore morphogenesis. DNA microarrays containing nearly every yeast gene were used to assay changes in gene expression during sporulation. At least seven distinct temporal patterns of induction were observed. The transcription factor Ndt80 appeared to be important for induction of a large group of genes at the end of meiotic prophase. Consensus sequences known or proposed to be responsible for temporal regulation could be identified solely from analysis of sequences of coordinately expressed genes. The temporal expression pattern provided clues to potential functions of hundreds of previously uncharacterized genes, some of which have vertebrate homologs that may function during gametogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chu, S -- DeRisi, J -- Eisen, M -- Mulholland, J -- Botstein, D -- Brown, P O -- Herskowitz, I -- AI18738/AI/NIAID NIH HHS/ -- GH00450/GH/CGH CDC HHS/ -- GM46406/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1998 Oct 23;282(5389):699-705.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143-0448, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9784122" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromosomes, Fungal/physiology ; *DNA-Binding Proteins ; Fungal Proteins/genetics/metabolism ; *Gene Expression Regulation, Fungal ; Genes, Fungal ; Genome, Fungal ; Humans ; Meiosis/*genetics ; Morphogenesis ; Organelles/ultrastructure ; Saccharomyces cerevisiae/*genetics/physiology ; *Saccharomyces cerevisiae Proteins ; Spores, Fungal/*genetics/physiology/ultrastructure ; Transcription Factors/genetics/metabolism ; *Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Regulating natural health products (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-04-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herskowitz, Ira -- New York, N.Y. -- Science. 2002 Apr 5;296(5565):46-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11962491" target="_blank"〉PubMed〈/a〉
    Keywords: Bicyclo Compounds ; Drug Interactions ; *Drug Labeling ; Humans ; Hypericum/*adverse effects ; Phloroglucinol/analogs & derivatives ; Phytotherapy/*adverse effects ; Plant Preparations/*adverse effects ; Terpenes/adverse effects/metabolism ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Isolation of ORC6, a component of the yeast origin recognition complex by a one-hybrid system (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-12-17
    Description: Here a method is described to identify genes encoding proteins that recognize a specific DNA sequence. A bank of random protein segments tagged with a transcriptional activation domain is screened for proteins that can activate a reporter gene containing the sequence in its promoter. This strategy was used to identify an essential protein that interacts in vivo with the yeast origin of DNA replication. Matches between its predicted amino acid sequence and peptide sequence obtained from the 50-kilodalton subunit of the yeast origin recognition complex (ORC) established that the gene isolated here, ORC6, encodes this subunit. These observations provide evidence that ORC recognizes yeast replication origins in vivo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, J J -- Herskowitz, I -- AI18738/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1993 Dec 17;262(5141):1870-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California, San Francisco 94143-0448.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8266075" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Cell Cycle ; *DNA Replication ; DNA, Fungal/metabolism ; DNA-Binding Proteins/chemistry/*genetics/metabolism ; Fungal Proteins/chemistry/*genetics/metabolism ; *Genes, Fungal ; Genes, Reporter ; Molecular Sequence Data ; Open Reading Frames ; Origin Recognition Complex ; Promoter Regions, Genetic ; *Replicon ; Repressor Proteins/chemistry/*genetics/metabolism ; Saccharomyces cerevisiae/cytology/*genetics/metabolism ; Saccharomyces cerevisiae Proteins
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Cell cycle control by a complex of the cyclin HCS26 (PCL1) and the kinase PHO85 (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-11-25
    Description: The events of the eukaryotic cell cycle are governed by cyclin-dependent kinases (cdk's), whose activation requires association with cyclin regulatory subunits expressed at specific cell cycle stages. In the budding yeast Saccharomyces cerevisiae, the cell cycle is thought to be controlled by a single cdk, CDC28. Passage through the G1 phase of the cell cycle is regulated by complexes of CDC28 and G1 cyclins (CLN1, CLN2, and CLN3). A putative G1 cyclin, HCS26, has recently been identified. In a/alpha diploid cells lacking CLN1 and CLN2, HCS26 is required for passage through G1. HCS26 does not associate with CDC28, but instead associates with PHO85, a closely related protein kinase. Thus, budding yeast, like higher eukaryotes, use multiple cdk's in the regulation of cell cycle progression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Espinoza, F H -- Ogas, J -- Herskowitz, I -- Morgan, D O -- AI18738/AI/NIAID NIH HHS/ -- CA52481/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1994 Nov 25;266(5189):1388-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, University of California, San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7973730" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; CDC28 Protein Kinase, S cerevisiae/metabolism ; Cyclin-Dependent Kinases/*metabolism ; Cyclins/*metabolism ; Fungal Proteins/*metabolism ; *G1 Phase ; Molecular Sequence Data ; Saccharomyces cerevisiae/*cytology/genetics ; *Saccharomyces cerevisiae Proteins ; Transcription Factors/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Phosphorylation of the transcription factor PHO4 by a cyclin-CDK complex, PHO80-PHO85 (1994)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1994-02-25
    Description: Induction of the yeast gene PHO5 is mediated by the transcription factors PHO2 and PHO4. PHO5 transcription is not detectable in high phosphate; it is thought that the negative regulators PHO80 and PHO85 inactivate PHO2 and PHO4. Here it is reported that PHO80 has homology to yeast cyclins and interacts with PHO85, a p34cdc2/CDC28-related protein kinase. The PHO80-PHO85 complex phosphorylates PHO4; this phosphorylation is correlated with negative regulation of PHO5. These results demonstrate the existence of a cyclin-cdk complex that is used for a regulatory process other than cell-cycle control and identify a physiologically relevant substrate for this complex.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kaffman, A -- Herskowitz, I -- Tjian, R -- O'Shea, E K -- New York, N.Y. -- Science. 1994 Feb 25;263(5150):1153-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉School of Medicine, Department of Biochemistry and Biophysics, University of California at San Francisco 94143.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8108735" target="_blank"〉PubMed〈/a〉
    Keywords: Acid Phosphatase/*biosynthesis/genetics ; Amino Acid Sequence ; Culture Media ; *Cyclin-Dependent Kinases ; *Cyclins ; *DNA-Binding Proteins ; Fungal Proteins/*metabolism ; Gene Expression Regulation, Fungal ; Models, Genetic ; Molecular Sequence Data ; Phosphates/metabolism ; Phosphorylation ; Repressor Proteins/*metabolism ; Saccharomyces cerevisiae/enzymology/genetics/*metabolism ; *Saccharomyces cerevisiae Proteins ; *Transcription Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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