Publication Date:
2002-10-26
Description:
The insulin/IGF-1 (where IGF-1 is insulin-like growth factor-1) signaling pathway influences longevity, reproduction, and diapause in many organisms. Because of the fundamental importance of this system in animal physiology, we asked when during the animal's life it is required to regulate these different processes. We find that in Caenorhabditis elegans, the pathway acts during adulthood, to relatively advanced ages, to influence aging. In contrast, it regulates diapause during development. In addition, the pathway controls longevity and reproduction independently of one another. Together our findings show that life-span regulation can be dissociated temporally from phenotypes that might seem to decrease the quality of life.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dillin, Andrew -- Crawford, Douglas K -- Kenyon, Cynthia -- 5RO1AG11816/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):830-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143-0448, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399591" target="_blank"〉PubMed〈/a〉
Keywords:
Aging
;
Animals
;
Caenorhabditis elegans/genetics/growth & development/metabolism/*physiology
;
Caenorhabditis elegans Proteins/genetics/physiology
;
DEAD-box RNA Helicases
;
Forkhead Transcription Factors
;
Insulin/*physiology
;
Insulin-Like Growth Factor I/*physiology
;
Life Cycle Stages/physiology
;
Longevity
;
Mutation
;
Oxidative Stress
;
RNA Helicases/genetics/physiology
;
RNA Interference
;
Receptor, Insulin/genetics/*physiology
;
Reproduction
;
*Signal Transduction
;
Temperature
;
Transcription Factors/genetics/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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