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  • Aerospace Medicine  (13)
  • AIRCRAFT DESIGN, TESTING AND PERFORMANCE  (5)
  • Analytical Chemistry and Spectroscopy  (5)
  • 1
    Publication Date: 2019-07-18
    Description: Introduction: Continuously evolving medical standards of care, limited crew training time, and the inherent constraints of space flight necessitate regular revisions of the mission medical support infrastructure and methodology. A three-day Operational and Research Musculoskeletal Summit was held to review NASA s current strategy for preflight health maintenance and injury screening, risk mitigation for musculoskeletal injuries or syndromes, treatment methods during flight, and research topics to mitigate risks to astronaut health. The Summit also undertook consideration of the best evidence-based terrestrial musculoskeletal practices to recommend their adaptation for use in space. Methods: The types and frequencies of musculoskeletal injuries sustained by short- and long-duration astronauts were obtained from the Longitudinal Study of Astronaut Health. The Summit panel was comprised of experts from the clinical and research communities, as well as representatives from NASA Headquarters, the Astronaut corps, and the offices of JSC Medical Operations, JSC Human Adaptation and Countermeasures, Glenn Research Center Human Research, and Astronaut Strength Conditioning and Rehabilitation. Before the summit, panelists participated in a Web-based review of NASA s Space Medical Conditions List (SMCL). Results: The Summit generated seventy-five operational and research recommendations to the NASA Office of Space Medicine, including changes to the SMCL and to the musculoskeletal section of the ISS debrief questionnaire. From these recommendations, seven were assigned highest value and priority, and could be immediately adopted for the exploration architecture. Discussion: Optimized exercise and conditioning to improve performance and forestall musculoskeletal damage on orbit were the primary area of focus. Special attention was paid to exercise timing and muscle group specificity. The panel s recommendations are currently in various stages of consideration or integration into the ISS and Exploration programs. This effort serves to enhance the on-orbit system so comprehensive treatment can be delivered in a more effective and standardized manner.
    Keywords: Aerospace Medicine
    Type: AsMA Annual Conference; May 06, 2007 - May 10, 2007; New Orleans, LA; United States
    Format: text
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  • 2
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 3 (1971), S. 127-138 
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Routine measurement of triton magnetic resonance spectra is described for the first time, using a micro-bulb sample tube assembly to obviate radiological hazards. Levels of isotope abundance and chemical concentration, the problem of self-radiolysis and the general usefulness of the technique are discussed. Results are given for a selection of compounds including glucose, amino-acids, thymidine and uridine. The self-radiolysis of the last is followed.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1969), S. 795-799 
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Comparison of the acetyl-, trifluoroacetyl-, benzyloxycarbonyl-, methoxycarbonyl-, ethoxycarbonyl, methylaminocarbonyl, phenylaminocarbonyl-, phthanoyl-, and stearoyl-derivatives of glycylleucylphenylalanine methyl ester has shown that acetyl derivative is the most volatile. The relative abundances of the sequence ions in the mass spectra od these compounds have been determined and compared: the acetyl derivative provides the best combination of volatility and abundance of sequence ions. Evidence is presented to show that the use of acid-catalysed esterification procedure for the chemical modification of peptides prior to mas spectrometric investigation can lead to degraded derivatives.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 2 (1970), S. 337-339 
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Measurements are reported on the nuclear magnetic resonance spectra of the acetyl protons of a series of substituted acetophenones. Although the extreme values of the chemical shifts, δCOCH3 for the meta- and para- substituted compounds differ only by 0·2 units, the values themselves are linearly related to the Hammett substituent constants. No such relationship exists for the ortho-substituted compounds. The magnitude of the chemical shift is independent of substrate concentration over a five-fold variation.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0749-1581
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 9 (1982), S. 429-437 
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The following indole compounds have been unequivocally identified and semi-quantitated in culture supernatants of Rhizobium strains by gas chromatography mass spectrometry: indole-3-aldehyde, trytophol, indole-3-carboxylic acid, indole-3-glycollc acid, indole-3-actic acid, indole-3-glyoxylic acid, N-acethyl-L-tryptophan and indole-3-pyruvic acid, as well as indole-3-acetic acid. The strains included a number of chosen Rhizobium mutants defective in various stages of nodule formation, and the biological implications of the findings are discussed. Two alternative approaches to sample purification were taken, one based primarily on solvent partitioning and the other on high-performance liquid chromatography. The advantages of each method are discussed. Gas chromatographic retention times and mass spectra are given for the TMS derivatives of 17 authentic indole standards.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2011-08-24
    Description: OBJECTIVES: The risk of a urinary calculus during an extended duration mission into the reduced gravity environment of space is significant. For medical operations to develop a comprehensive strategy for the spaceflight stone risk, both preventive countermeasures and contingency management (CM) plans must be included. METHODS: A feasibility study was conducted to demonstrate the potential CM technique of endoscopic ureteral stenting with ultrasound guidance for the possible in-flight urinary calculus contingency. The procedure employed the International Space Station/Human Research Facility ultrasound unit for guide wire and stent localization, a flexible cystoscope for visual guidance, and banded, biocompatible soft ureteral stents to successfully stent porcine ureters bilaterally in zero gravity (0g). RESULTS: The study demonstrated that downlinked endoscopic surgical and ultrasound images obtained in 0g are comparable in quality to 1g images, and therefore are useful for diagnostic clinical utility via telemedicine transmission. CONCLUSIONS: In order to be successful, surgical procedures in 0g require excellent positional stability of the operating surgeon, assistant, and patient, relative to one another. The technological development of medical procedures for long-duration spaceflight contingencies may lead to improved terrestrial patient care methodology and subsequently reduced morbidity.
    Keywords: Aerospace Medicine
    Type: Urology (ISSN 0090-4295); Volume 53; 5; 892-7
    Format: text
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  • 8
    Publication Date: 2019-06-28
    Description: A simplified cylindrical model of an aircraft fuselage is used to experimentally study the effects of an internal floor on low frequency sound transmission into aircraft cabins. A scaled-down lattice floor support and floor skin are designed based upon selected characteristics of a business aircraft. Thus, the model provides a simplified procedure for studying the effects of various structural modifications as well as other important effects. Modal decomposition of the shell response and the corresponding pressure response at various interior locations are presented. Results indicate that the main effect of the floor on interior pressure levels is due to modification of the interior acoustic mode shape and not due to the structural modification of the fuselage caused by the lattice floor support.
    Keywords: AIRCRAFT DESIGN, TESTING AND PERFORMANCE
    Type: AIAA PAPER 86-1939
    Format: text
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  • 9
    Publication Date: 2019-06-28
    Description: A simplified cylindrical model of an aircraft fuselage is used to investigate the mechanisms of interior noise suppression of the synchrophasing technique. This investigation allows isolation of important parameters to define the characteristics of synchrophasing. The optimum synchrophase angle for maximum noise reduction is found for several interior microphone positions with pure tone source conditions. Noise reductions of up to 30dB are shown for some microphone positions, however, overall reductions are less. A computer algorithm is developed to decompose the modal composition of the cylinder vibration over a wide range of synchrophase angles. The circumferential modal response of the shell vibration is shown to govern the transmission of sound into the cylinder rather than localized transmission.
    Keywords: AIRCRAFT DESIGN, TESTING AND PERFORMANCE
    Type: AIAA PAPER 84-2370
    Format: text
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  • 10
    Publication Date: 2019-07-19
    Description: Elevated bone resorption is a hallmark of human spaceflight and bed rest indicating that elevated remodeling is a major factor in the etiology of space flight bone loss. In a collaborative effort between the NASA and JAXA space agencies, we are testing whether an antiresorptive drug would provide additional benefit to in-flight exercise to ameliorate bone loss and hypercalciuria during long-duration spaceflight. Measurements of bone loss include DXA, QCT, pQCT, urinary and blood biomarkers. We have completed analysis of R+1year data from 7 crewmembers treated with alendronate during flight, as well as immediate post flight (R+〈2wks) data from 6 of 10 concurrent controls without treatment. The treated astronauts used the Advanced Resistive Exercise Device (ARED) during their missions. The purpose of this report is twofold: 1) to report the results of inflight, post flight and one year post flight bone measures compared with available controls with and without the use of ARED; and 2) to discuss preliminary data on concurrent controls. The figure below compares the BMD changes in ISS crewmembers exercising with and without the current ARED protocol and the alendronate treated crewmembers also using the ARED. This shows that the use of ARED prevents about half the bone loss seen in early ISS crewmembers and that the addition of an antiresorptive provides additional benefit. Resorption markers and urinary Ca excretion are not impacted by exercise alone but are significantly reduced with antiresorptive treatment. Bone measures for treated subjects, 1 year after return from space remain at or near baseline. DXA data for the 6 concurrent controls using the ARED device are similar to DXA data shown in the figure below. QCT data for these six indicate that the integral data are consistent with the DXA data, i.e., comparing the two control groups suggests significant but incomplete improvement in maintaining BMD using the ARED protocol. Biochemical data of the concurrent control group await sample return and analysis. The preliminary conclusion is that an antiresorptive may be an effective adjunct to exercise during long-duration spaceflight.
    Keywords: Aerospace Medicine
    Type: JSC-CN-32238 , 2015 Human Research Program Investigators'' Workshop (HRP IWS 2015); Jan 13, 2015 - Jan 15, 2015; Galveston, TX; United States
    Format: application/pdf
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