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Determination of the binding of β-cyclodextrin derivatives to adamantane carboxylic acids using capillary electrophoresis (1996)

Kwak, E. -S. ; Gomez, F. A.

Springer

Chromatographia 43 (1996), S. 659-662

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ISSN: 1612-1112

Keywords: Capillary electrophoresis ; Adamantane derivatives ; 3-Cyclodextrin ; Indirect detection

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Summary Binding constants between adamantane carboxylic acids and β-cyclodextrin derivatives were determined by capillary electrophoresis (CE) using indirect detection. In this procedure, a mixture of adamantane derivative and non-interacting anionic standards, is injected and analysis of the electrophoretic mobility, relative to the noninteracting anionic standards, as a function of the concentration of cyclodextrin, yields values for their binding constants to the adamantane derivative. The usefulness of the method for quantification of binding constants is demonstrated.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02292984

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