ISSN:
1573-0646
Keywords:
gemcitabine
;
colorectal cancer
;
phase II
;
150 minutes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Metastatic colorectal cancer is very common in the Western hemisphere and current treatment modalities are not effective. In this study a prolonged (150-minute) infusion of gemcitabine at a constant dose rate of 10 mg/m2/min administered weekly for 3 consecutive weeks repeated every 4 weeks revealed a response rate of 4% (90% CI 〈 1%–18%). There were no complete responses. Treatment with gemcitabine produced moderate to severe toxicity as grade 3–4 neutropenia requiring dose modification was seen in 40% of patients treated. When used in this dose and schedule, gemcitabine does not appear to be effective for patients with metastatic colorectal cancer.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1006100116229
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