ISSN:
0749-1581
Keywords:
1H
;
13C and 31P NMR spectra
;
chiral P-substituted 1,3,2-dioxaphosphorinanes
;
conformational analysis
;
spin simulation
;
double resonance
;
2D-J experiments
;
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
13C, 1H and 31P NMR investigations have been carried out to determine the ring stereochemistry and phosphorus configuration for four chiral (4R, 6R)-2-substituted-1,3,2-dioxaphosphorinane derivatives 1-4 (2-substituent = Cl, Ph, OMe and O-t-Bu, respectively). 1H NMR spectra, double resonance, 2D-J experiments and spin simulation proved the chair character of the ring. Depending on the position of R, two diastereomers may exist, but in most cases only one predominating form was detected. Dynamic processes were observed for 1 and 2. Saturation transfer experiments proved the existence of ring and/or phosphorus inversions.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/mrc.1260241009
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