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Synthesis of a new neoglycopeptide for inhibition of lactose permease (1999)

Kienle, Stefan ; Nollert, Peter ; Wiesmüller, Karl-Heinz

Springer

International journal of peptide research and therapeutics 6 (1999), S. 143-149

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ISSN: 1573-3904

Keywords: lactose permease ; neoglycopeptide ; 1-thio-β-d-galactoside ; transport inhibition

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Summary A new neoglycopeptide was synthesized and tested for its capability to bind to lactose permease ofEscherichia coli and to inhibit the transport of lactose. The free 5′-carboxypentyl-1-thio-β-d-galactopyranoside or the protected 2,3,4,6-tetra-O-acetyl-5′-carboxypentyl-1-thio-β-d-galactopyranoside was linked to the N-terminal α-amino group of the resin bound heptapeptide H-Phe-Phe-Gly-Gly-Gly-Gly-Ala-OH by different activation methods. Upon cleavage from the resin, deacetylation and purification, a neoglycopeptide which showed a significant inhibition of lactose permease was obtained.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02443629

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