Publication Date:
2008-11-22
Description:
Every organ depends on blood vessels for oxygen and nutrients, but the vasculature associated with individual organs can be structurally and molecularly diverse. The central nervous system (CNS) vasculature consists of a tightly sealed endothelium that forms the blood-brain barrier, whereas blood vessels of other organs are more porous. Wnt7a and Wnt7b encode two Wnt ligands produced by the neuroepithelium of the developing CNS coincident with vascular invasion. Using genetic mouse models, we found that these ligands directly target the vascular endothelium and that the CNS uses the canonical Wnt signaling pathway to promote formation and CNS-specific differentiation of the organ's vasculature.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stenman, Jan M -- Rajagopal, Jay -- Carroll, Thomas J -- Ishibashi, Makoto -- McMahon, Jill -- McMahon, Andrew P -- DK054364/DK/NIDDK NIH HHS/ -- HL076393/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2008 Nov 21;322(5905):1247-50. doi: 10.1126/science.1164594.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19023080" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Blood-Brain Barrier/*embryology
;
Central Nervous System/*blood supply/*embryology
;
Embryonic Induction
;
Mice
;
Mutation
;
*Neovascularization, Physiologic
;
Neuroepithelial Cells/physiology
;
Proto-Oncogene Proteins/genetics/*physiology
;
*Signal Transduction
;
Wnt Proteins/genetics/*physiology
;
beta Catenin/physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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