Publication Date:
2002-08-31
Description:
Spatially or chemically isolated functional modules composed of several cellular components and carrying discrete functions are considered fundamental building blocks of cellular organization, but their presence in highly integrated biochemical networks lacks quantitative support. Here, we show that the metabolic networks of 43 distinct organisms are organized into many small, highly connected topologic modules that combine in a hierarchical manner into larger, less cohesive units, with their number and degree of clustering following a power law. Within Escherichia coli, the uncovered hierarchical modularity closely overlaps with known metabolic functions. The identified network architecture may be generic to system-level cellular organization.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ravasz, E -- Somera, A L -- Mongru, D A -- Oltvai, Z N -- Barabasi, A L -- New York, N.Y. -- Science. 2002 Aug 30;297(5586):1551-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, University of Notre Dame, Notre Dame, IN 46556, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12202830" target="_blank"〉PubMed〈/a〉
Keywords:
Escherichia coli/metabolism
;
*Metabolism
;
*Models, Biological
;
Systems Theory
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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