Publication Date:
1992-08-07
Description:
Antigen-specific T cell activation depends on T cell receptor-ligand interaction and costimulatory signals generated when accessory molecules bind to their ligands, such as CD28 to the B7 (also called BB1) molecule. A soluble fusion protein of human CTLA-4 (a protein homologous to CD28) and the immunoglobulin (lg) G1 Fc region (CTLA4lg) binds to human and murine B7 with high avidity and blocks T cell activation in vitro. CTLA4lg therapy blocked human pancreatic islet rejection in mice by directly affecting T cell recognition of B7+ antigen-presenting cells. In addition, CTLA4lg induced long-term, donor-specific tolerance, which may have applications to human organ transplantation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lenschow, D J -- Zeng, Y -- Thistlethwaite, J R -- Montag, A -- Brady, W -- Gibson, M G -- Linsley, P S -- Bluestone, J A -- AI29531/AI/NIAID NIH HHS/ -- R29 DK40092/DK/NIDDK NIH HHS/ -- New York, N.Y. -- Science. 1992 Aug 7;257(5071):789-92.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ben May Institute, University of Chicago, IL 60637.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1323143" target="_blank"〉PubMed〈/a〉
Keywords:
Abatacept
;
Animals
;
Antibodies, Monoclonal/therapeutic use
;
Antigens, CD
;
Antigens, Differentiation/immunology/*therapeutic use
;
CTLA-4 Antigen
;
Diabetes Mellitus, Experimental/*surgery
;
Graft Survival/*immunology/physiology
;
Humans
;
*Immunoconjugates
;
Immunoglobulin Fc Fragments
;
Immunoglobulin G
;
Immunosuppressive Agents/*therapeutic use
;
Islets of Langerhans Transplantation/*immunology/physiology
;
Mice
;
Mice, Inbred Strains
;
Phosphates/analysis/*metabolism
;
Receptors, Cell Surface/immunology
;
Recombinant Fusion Proteins/*therapeutic use
;
Time Factors
;
Transplantation, Heterologous/*immunology/physiology
;
Uranium/analysis/*metabolism
;
*Uranium Compounds
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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