Publication Date:
2012-03-17
Description:
Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported more than 10,000 mismatches between messenger RNA and DNA sequences from the same individuals, which they attributed to previously unrecognized mechanisms of gene regulation. We found that at least 88% of these sequence mismatches can likely be explained by technical artifacts such as errors in mapping sequencing reads to a reference genome, sequencing errors, and genetic variation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pickrell, Joseph K -- Gilad, Yoav -- Pritchard, Jonathan K -- GM077959/GM/NIGMS NIH HHS/ -- MH084703/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2012 Mar 16;335(6074):1302; author reply 1302. doi: 10.1126/science.1210484.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA. pickrell@uchicago.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22422963" target="_blank"〉PubMed〈/a〉
Keywords:
DNA/*genetics
;
*Genetic Variation
;
*Genome, Human
;
Humans
;
RNA, Messenger/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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