Publication Date:
2005-04-16
Description:
We used wounded Drosophila embryos to define an evolutionarily conserved pathway for repairing the epidermal surface barrier. This pathway includes a wound response enhancer from the Ddc gene that requires grainy head (grh) function and binding sites for the Grh transcription factor. At the signaling level, tyrosine kinase and extracellular signal-regulated kinase (ERK) activities are induced in epidermal cells near wounds, and activated ERK is required for a robust wound response. The conservation of this Grh-dependent pathway suggests that the repair of insect cuticle and mammal skin is controlled by an ancient, shared control system for constructing and healing the animal body surface barrier.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mace, Kimberly A -- Pearson, Joseph C -- McGinnis, William -- R01HD28315/HD/NICHD NIH HHS/ -- T32GM07240/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2005 Apr 15;308(5720):381-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Section of Cell and Developmental Biology, Division of Biology, University of California, San Diego, La Jolla, CA 92093, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15831751" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Base Sequence
;
Binding Sites
;
Cyclic AMP Response Element-Binding Protein/metabolism
;
DNA-Binding Proteins/genetics/*metabolism
;
Dopa Decarboxylase/*genetics/metabolism
;
Drosophila Proteins/genetics/metabolism
;
Drosophila melanogaster/*embryology/genetics/physiology
;
Embryo, Nonmammalian/*physiology
;
Enhancer Elements, Genetic
;
Epidermis/*embryology/physiology
;
Epithelium/physiology
;
Extracellular Signal-Regulated MAP Kinases/metabolism
;
*Gene Expression Regulation
;
Genes, Homeobox
;
Genes, Insect
;
Homeodomain Proteins/genetics
;
MAP Kinase Signaling System
;
Molecular Sequence Data
;
Mutation
;
NF-kappa B/metabolism
;
Nuclear Proteins/genetics
;
Transcription Factor AP-1/metabolism
;
Transcription Factors/genetics/*metabolism
;
Transcription, Genetic
;
Tyrosine 3-Monooxygenase/genetics/metabolism
;
Wound Healing
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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