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  • Engineering (General)  (3)
  • *Enhancer Elements, Genetic  (1)
  • 1
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    Epigenomic enhancer profiling defines a signature of colon cancer (2012)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2012-04-14
    Description: Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, even though distal regulatory elements play a central role in controlling transcription patterns. We used the histone mark H3K4me1 to analyze gain and loss of enhancer activity genome-wide in primary colon cancer lines relative to normal colon crypts. We identified thousands of variant enhancer loci (VELs) that comprise a signature that is robustly predictive of the in vivo colon cancer transcriptome. Furthermore, VELs are enriched in haplotype blocks containing colon cancer genetic risk variants, implicating these genomic regions in colon cancer pathogenesis. We propose that reproducible changes in the epigenome at enhancer elements drive a specific transcriptional program to promote colon carcinogenesis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711120/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3711120/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Akhtar-Zaidi, Batool -- Cowper-Sal-lari, Richard -- Corradin, Olivia -- Saiakhova, Alina -- Bartels, Cynthia F -- Balasubramanian, Dheepa -- Myeroff, Lois -- Lutterbaugh, James -- Jarrar, Awad -- Kalady, Matthew F -- Willis, Joseph -- Moore, Jason H -- Tesar, Paul J -- Laframboise, Thomas -- Markowitz, Sanford -- Lupien, Mathieu -- Scacheri, Peter C -- 1P50CA150964/CA/NCI NIH HHS/ -- 5T32GM008056-29/GM/NIGMS NIH HHS/ -- P20 GM103534/GM/NIGMS NIH HHS/ -- P50 CA150964/CA/NCI NIH HHS/ -- R01 CA155004/CA/NCI NIH HHS/ -- R01 CA160356/CA/NCI NIH HHS/ -- R01 LM009012/LM/NLM NIH HHS/ -- R01 LM010098/LM/NLM NIH HHS/ -- R01-LM009012/LM/NLM NIH HHS/ -- R01-LM010098/LM/NLM NIH HHS/ -- R01CA1555004/CA/NCI NIH HHS/ -- R01CA160356/CA/NCI NIH HHS/ -- R01HD056369/HD/NICHD NIH HHS/ -- U01 CA152756/CA/NCI NIH HHS/ -- UL1 RR024989/RR/NCRR NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2012 May 11;336(6082):736-9. doi: 10.1126/science.1217277. Epub 2012 Apr 12.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22499810" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line, Tumor ; Chromatin Immunoprecipitation ; Colon/metabolism ; Colonic Neoplasms/*genetics/metabolism ; *Enhancer Elements, Genetic ; *Epigenesis, Genetic ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Genes, Neoplasm ; Genetic Loci ; Histones/*metabolism ; Humans ; Intestinal Mucosa/metabolism ; Methylation ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; *Transcriptome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Hardware Assessment in Support of the Dynamic Power Convertor Development Effort (2017)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Stirling Radioisotope Power Systems (RPS) are being developed by NASA's RPS Program in collaboration with the U.S. Department of Energy (DOE). Efforts ranging from 2001 to 2015 enabled development of the Technology Demonstration Convertor (TDC) for use in the 110-watt Stirling Radioisotope Generator (SRG-110) and the Advanced Stirling Convertor (ASC) for use in the Advanced Stirling Radioisotope Generator (ASRG). The DOE selected Lockheed Martin Space Systems Company (LMSSC) as the system integration contractor for both flight development efforts. The SRG-110 housed two TDCs fabricated by Infinia and resulted in the production of 16x demonstration units and 2x engineering units. The project was redirected in 2006 to make use of a more efficient and lower mass ASCs under development by Sunpower Inc. The DOE managed the flight contract with LMSSC and subcontractor Sunpower Inc. from 2007 to 2013 to build the ASRG, with support from NASA Glenn Research Center (GRC). Sunpower Inc. held two parallel contracts to produce ASCs, one with Lockheed Martin to produce ASC-F flight units and one with GRC for the production of ASC-E3 engineering unit pathfinders that were used to refine the flight design and production processes. The DOE initiated termination of the ASRG contract in late 2013. After ASRG had ended, GRC completed characterization testing of the ASRG Engineering Unit #2 (EU2) and the GRC contract with Sunpower was also completed. The NASA RPS Program Office has recently initiated a new Dynamic Power Conversion development effort which includes the potential maturation of Stirling, Brayton, and Rankine power convertors for the next generation of RPS. The effort started with the request for proposal and review of submits. Contracts are anticipated for release in 2017 and will initially focus on a design phase prior to fabrication and testing. This new effort will focus on robustness in addition to high efficiency, specific power, and reliability. Also, some requirements introduced during the ASRG contract have also been included in the new effort, such as constant lateral loading. Due to the focus on robustness and new requirements relative to the older TDC design, the Stirling Cycle Development Project has initiated an assessment of government owned hardware to help inform requirements evolution and evaluation of future designs. While lessons learned from the ASRG flight development project have been taken into consideration, the evaluation of the TDC design had not been completed for some existing environments or relatively new requirements. To further assess the TDC design, a series of tasks were initiated to evaluate degradation for units that have operated unattended for over 105,000 hours, demonstrate robustness to a random vibration environment, characterize and evaluate performance for varying lateral load profiles. The status for each task are described.
    Keywords: Engineering (General)
    Type: GRC-E-DAA-TN43782 , International Energy Conversion Engineering Conference; Jul 10, 2017 - Jul 12, 2017; Atlanta, GA; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 3
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    Dynamic Radioisotope Power Systems: Convertor Development at NASA GRC (2018)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: NASA's dynamic power convertor development in support of high-efficiency RPS is progressing as planned, and shows promise. This presentation gives dynamic conversion power system background, development path, and key convertor performance goals. It also gives information on the Flexure Isotope Stirling Convertor, Turbo-Brayton Convertor, Thermo-Acoustic Power Convertor, Sunpower Robust Stirling Convertor, Stirling Convertor Extended Operation, TDC #14 Disassembly and Inspection, and Launch Vibration Exposure on SES #2.
    Keywords: Engineering (General)
    Type: GRC-E-DAA-TN56093 , 2018 Power Community TDT/CLT; May 02, 2018; Cleveland, OH; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Status of Dynamic Power Convertor Development for RPS at NASA GRC (2018)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: NASA's dynamic power convertor development in support of high-efficiency RPS is progressing as planned, and shows promise. Ongoing research utilizing existing hardware supports viability of dynamic power conversion for RPS.
    Keywords: Engineering (General)
    Type: GRC-E-DAA-TN55689 , IAPG Mechanical Working Group Meeting; May 01, 2018 - May 03, 2018; Philadelphia, PA; United States
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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