Publication Date:
2017-03-09
Description:
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function Nature 543, 7644 (2017). doi:10.1038/nature21358 Authors: Pascal Drané, Marie-Eve Brault, Gaofeng Cui, Khyati Meghani, Shweta Chaubey, Alexandre Detappe, Nishita Parnandi, Yizhou He, Xiao-Feng Zheng, Maria Victoria Botuyan, Alkmini Kalousi, William T. Yewdell, Christian Münch, J. Wade Harper, Jayanta Chaudhuri, Evi Soutoglou, Georges Mer & Dipanjan Chowdhury P53-binding protein 1 (53BP1) is a multi-functional double-strand break repair protein that is essential for class switch recombination in B lymphocytes and for sensitizing BRCA1-deficient tumours to poly-ADP-ribose polymerase-1 (PARP) inhibitors. Central to all 53BP1 activities is its recruitment to double-strand breaks via the interaction
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
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Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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