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  • 1
    Electronic Resource
    Electronic Resource
    Systems analysis in cell biology: From the phenomenological description towards a computer model of the intracellular signal transduction network (1993)
    Springer
    Cellular and molecular life sciences 49 (1993), S. 245-257 
    Details
    ISSN: 1420-9071
    Keywords: Structured analysis ; mathematical modelling ; stochastic simulation ; cell cycle control ; tumor biology ; calcium oscillations ; signal transduction ; Structured Biological Modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In this paper we introduce a systematic approach for the modelling of complex biological systems which is especially useful for the analysis of signal transduction mechanisms in cell biology. It is shown that systems analysis in form of top-down levelled dataflow diagrams provides a powerful tool for the mathematical modelling of the system in terms of a stochastic formulation. Due to the exact formulation, the consistency of the model with the experimental results can be tested by means of a computer simulation. The method termed Structured Biological Modelling (SBM) is illustrated by modelling some aspects of the second messenger network which regulates cell proliferation. As an example for the strainghtforward development of a mathematical description a stochastic computer model for intracellular Ca2+ oscillations is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01923534
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  • 2
    Electronic Resource
    Electronic Resource
    Reactivity of juxtaglomerular granule cells to changes in sodium and potassium intake in the absence of the adrenal bodies (1970)
    Springer
    Cellular and molecular life sciences 26 (1970), S. 374-376 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Chez les rats adrénalectomisés, une différence très nette de l'indice de la granularité juxtaglomérulaire est apparue entre les animaux qui avaient bu du 2% NaCl et ceux qui avaient reçu ou de l'eau distillée ou du 2% KCl. Il y a donc une réactivité juxtaglomérulaire, indépendente du cortex surrénal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01896896
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of stress and diazepam treatment during infancy on the corticosterone regulation and androgenic activity in adult male rats (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 62-63 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Stresseinwirkung in früher postnataler Ontogenese führt bei erwachsenen Ratten zu Veränderungen, die auf eine erhöhte Androgenaktivität hinweisen. Die Mehrheit dieser Veränderungen kann mittels Diazepam gehemmt werden.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01924680
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  • 4
    Electronic Resource
    Electronic Resource
    Modellbildung in der biologie (1992)
    Springer
    Naturwissenschaften 79 (1992), S. 289-299 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01138706
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  • 5
    Electronic Resource
    Electronic Resource
    rps10, unreported for plastid DNAs, is located on the cyanelle genome of Cyanophora paradoxa and is contranscribed with the str operon genes (1991)
    Springer
    Current genetics 19 (1991), S. 313-315 
    Details
    ISSN: 1432-0983
    Keywords: Cyanophora paradoxa ; Cyanelle ; rps10 ; str operon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary rps10, encoding the plastid ribosomal protein S10, is a nuclear gene in higher plants and green algae, and is missing from the large ribosomal protein gene cluster of chlorophyll b-type plastids that contains components of the prokaryotic S10, spc and alpha operons. The cyanelle genome of Cyanophora paradoxa is shown to harbor rps10 as another specific feature of its organization. However, this novel plastid gene is not contiguous with the genes of the “S10” operon, but is adjacent to, and cotranscribed with, the str operon, a trait also found in archaebacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00355061
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  • 6
    Electronic Resource
    Electronic Resource
    Cholinesterase reactivators — Contribution to the study of their metabolic effects (1976)
    Springer
    Cellular and molecular life sciences 32 (1976), S. 1446-1447 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Cholinesterase reactivators — trimedoxim, methoxim and obidoxim — injected in the dose of 20 mg/kg s.c., increase muscle glycogen concentration in normal, but not in adrenalectomized rats. This effect may be in connection with simoultaneously found rise of serum corticosteron level. Trimedoxim decreases adrenaline, methoxim and obidoxim noradrenaline concentration in adrenals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01937425
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  • 7
    Electronic Resource
    Electronic Resource
    The cyanelle str operon from Cyanophora paradoxa: Sequence analysis and phylogenetic implications (1990)
    Springer
    Plant molecular biology 15 (1990), S. 561-573 
    Details
    ISSN: 1573-5028
    Keywords: cyanelle ; Cyanophora paradoxa ; plastid evolution ; str operon ; phylogenetic analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The str operon containing the genes for the ribosomal proteins S12 (rps12) and S7 (rps7) and for the elongation factors G (fus) and Tu (tufA) has been characterized for some cyanobacteria and chloroplasts from algae and higher plants. In the case of plastids a stepwise reduction. by one and two genes, respectively, has been observed due to gene transfer to the nuclear genome. The nucleotide sequence of the str operon on the cyanelle genome from Cyanophora paradoxa was determined as a first example for a chlorophyll b-less plastid. It comprises rps12, rps7 and tufA which are closely linked and not interrupted by introns. Transcript analysis revealed cotranscription of the two ribosomal protein genes whereas tufA gave rise to a monocistronic mRNA. Phylogenetic studies using these three different traits allowed an assessment of the position of Cyanophora paradoxa among oxygenic photoautotrophs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00017831
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  • 8
    Electronic Resource
    Electronic Resource
    Some factors affecting the colonization of a dredged channel (1975)
    Springer
    Marine biology 32 (1975), S. 193-204 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Standing crop, population size, and species diversity of the macrobenthic organisms in an estuarine channel were studied before and after dredging. A new suction-corer which sampled an area 0.1 m2 to a depth of 30 cm was used in order to insure the inclusion of large, deep-dwelling animals. Eleven months after dredging, biomass and number of species and specimens had not recovered to pre-dredging levels. Colonization began with relatively large, swiftly moving forms such as the errant polychaete Nereis succinea and the crab Neopanope texana sayi. Stations in silt and mud regions recovered more slowly than those in sandier sediments. Most of the dominant and subdominant species had not recovered 11 months after dredging, and the previously abundant polychaetes Notomastus latericeus and Clymenella torquata had virtually disappeared. Only relatively uncommon lamellibranchs such as Tellina agilis, Lyonsia hyalina and Mulinia lateralis increased after dredging. Distribution of sediment types changed as the result of modified tidal velocities in the channel. Mud and silt were removed by the dredge, exposing the sand underneath, and sandy stations became muddier as the result of lowered current velocities. Marked changes in species composition reflected this change in sediment character. Eleven months after dredging no evidence of succession was found, but colonization had begun. Values of all three parameters studied were reduced to small fractions of pre-dredging levels, although species diversity in sandy sediments exceeded pre-dredging levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388512
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  • 9
    Electronic Resource
    Electronic Resource
    A six-minute determination of carbon and hydrogen with titrimetric finish (1964)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 205 (1964), S. 50-58 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Ein Verfahren zur C-H-Bestimmung wird beschrieben, bei dem die Endbestimmung volumetrisch erfolgt. Hierbei werden sowohl Kohlenstoff als auch Wasserstoff in äquivalente Mengen Kohlendioxid übergeführt und dieses durch Titration in nichtwäßrigem Medium erfaßt. Die Methode kann auch für die Analyse gaschromatographisch getrennter Substanzen benutzt werden. Eine Bestimmung ist innerhalb von 6 min beendet.
    Notes: Summary A method is described for the C/H determination with a completely titrimetric finish. Both carbon and hydrogen are converted to an equivalent amount of carbon dioxide, which is titrated in a non-aquous medium. The procedure can be applied for the analysis of substances separated by a gas Chromatograph. The determination takes about six minutes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00514586
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  • 10
    Electronic Resource
    Electronic Resource
    Water-soluble poly(acrylamide-allylamine) derivatives of saccharides for protein-saccharide binding studies (1995)
    Springer
    Glycoconjugate journal 12 (1995), S. 51-54 
    Details
    ISSN: 1573-4986
    Keywords: Water soluble polyacrylamide derivatives of saccharides ; protein-saccharide binding studies ; heparin coupled to polyacrylamide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Water-soluble poly(acrylamide-allylamine) copolymers containing covalently bound amino groups, prepared by copolymerization of acrylamide and allylamine, can be used as general carriers for coupling of different types of saccharides or saccharide derivatives. The water-soluble macromolecular carbohydrate derivatives can be easily labelled and used in various solid-phase techniques to study protein-saccharide interaction. Two types of coupling reaction were used to prepare polyacrylamide derivatives of saccharides: reductive amination was applied to couple the reducing disaccharides and a carbodiimide reaction was used to couple heparin via its carboxyl groups to the amino groups of the poly(acrylamide-allylamine) derivative. Peroxidase labelled or biotinylated derivatives were shown to be useful in studies on the binding properties of lectins and proteins from boar seminal plasma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00731868
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