ISSN:
1741-0444
Keywords:
Modelling
;
Parameter estimation
;
Ventricular pumping function
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract A simple model which represents a linear approximation of the pressurel volume/flow relationship extensively used for describing ventricular mechanics, especially in simulation studies, is developed. In this model, the left ventricle is represented by a pressure generator in series with viscous and elastic time-varying elements. Despite its simplicity, the model elucidates the intimate connections between some current approaches for characterising pulsatile ventricular behaviour. A conventional identification scheme was used to estimate viscous and elastic parameters from data measured in both isolated rabbit hearts and open-chest dogs. Their variations with preload and afterload are shown to reflect known local characteristics of the inherently nonlinear cardiac pump, which correspond also to relevant features at muscular level. These results, together with some recent experimental evidence, substantially support the finding that both viscosity and elastance vary with time in linear proportion to the isovolumic pressure.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02441622
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