ISSN:
1432-1432
Keywords:
Jukes and Cantor's model
;
Kimura's two-parameter model
;
Tamura and Nei's model
;
Gamma distances
;
Bias correction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract When the number of nucleotides examined is relatively small, the estimators of nucleotide substitutions between DNA sequences often introduce systematic error even if the data used fit the mathematical model underlying the estimation formula. The systematic error of this kind is especially large for models that allow variation in substitution rate among different sites. In the present paper we present a number of formulas that produce virtually bias-free estimates of evolutionary distances for these models.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00176091
Permalink