Publication Date:
2012-06-11
Description:
Background: Previous studies have examined the associations between polymorphisms of adiponectin gene(ADIPOQ) and cardiovascular disease (CVD), but those studies have been inconclusive. Theaim of this study was to access the relationship between three single nucleotidepolymorphisms (SNPs), +45 T 〉 G (rs2241766), +276 G 〉 T (rs1501299) and -11377 C 〉 G(rs266729) in ADIPOQ and CVD. Methods: A comprehensive search was conducted to identify all studies on the association of ADIPOQgene polymorphisms with CVD risk. The fixed and random effect pooled measures (i.e. oddsratio (OR) and 95% confidence interval (CI)) were calculated in the meta-analysis.Heterogeneity among studies was evaluated using Q test and the I2. Publication bias wasestimated using modified Egger's linear regression test. Results: Thirty-seven studies concerning the associations between the three polymorphisms ofADIPOQ gene and CVD risk were enrolled in this meta-analysis, including 6,398 cases and10,829 controls for rs2241766, 8,392 cases and 18,730 controls for rs1501299 and 7,835cases and 14,023 controls for rs266729. The three SNPs were significantly associated withCVD, yielding pooled ORs of 1.22 (95%CI: 1.07, 1.39; P = 0.004), 0.90 (95%CI: 0.83, 0.97;P = 0.007) and 1.09(95%CI: 1.01, 1.17; P = 0.032) for rs2241766, rs1501299 and rs266729,respectively. Rs2241766 and rs1501299 were significantly associated with coronary heartdisease (CHD), yielding pooled ORs of 1.29 (95%CI: 1.09, 1.52; P = 0.004) and 0.89(95%CI: 0.81, 0.99; P = 0.025), respectively. The pooled OR for rs266729 and CHD was1.09 (95%CI: 0.99, 1.19; P = 0.090). Significant between-study heterogeneity was found inour meta-analysis. Evidence of publication bias was observed in the meta-analysis. Conclusions: The present meta-analysis showed that the associations between rs2241766, rs1501299 andrs266729 in the ADIPOQ and CVD were significant but weak. High quality studies are stillneeded to confirm the associations, especially for rs2241766.
Electronic ISSN:
1471-2350
Topics:
Biology
,
Medicine
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