Publication Date:
2015-12-03
Description:
Objective To assess the argonaute 2 (Ago2) expression in the bone marrow of multiple myeloma (MM) and determine its association with angiogenesis. Methods Fifty-nine MM patients and sixteen normal controls were included. The bone marrow sections were made from plastic (methyl-methacrylate)- embedded bone marrow biopsies. The expression of Ago2 and CD34 in the bone marrow sections was detected by EnVison immunohistochemistry and the microvessel density (MVD) was then assessed. The bone marrow Ago2 expression level was also compared by western blot. The clinical significance of Ago2 expression and MVD in MM was analyzed. Results Western blot analysis indicated that the Ago2 expression was significantly increased in the bone marrow of MM patients as compared with normal controls. As assessed by immunohistochemistry, fifty MM patients were positive for Ago2 and nine patients were negative. However, sixteen normal controls were all negative for Ago2 (χ2=42.586,P
Print ISSN:
0006-4971
Electronic ISSN:
1528-0020
Topics:
Biology
,
Medicine
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