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  • 1
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    Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-09-27
    Description: The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8alpha+ dendritic cell subset. Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allan, Rhys S -- Smith, Chris M -- Belz, Gabrielle T -- van Lint, Allison L -- Wakim, Linda M -- Heath, William R -- Carbone, Francis R -- New York, N.Y. -- Science. 2003 Sep 26;301(5641):1925-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, The University of Melbourne, Melbourne, Victoria 3010, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14512632" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigen Presentation ; Antigens, CD/analysis ; Antigens, CD8/*analysis ; Antigens, Viral/immunology ; Cell Separation ; Chimera ; Cytotoxicity, Immunologic ; Dendritic Cells/*immunology ; Epidermis/*immunology ; H-2 Antigens/analysis/immunology ; Herpes Simplex/*immunology ; Herpesvirus 1, Human/*immunology ; Histocompatibility Antigens Class II/analysis ; Langerhans Cells/*immunology ; Lectins, C-Type/analysis ; Lymph Nodes/immunology ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Inbred Strains ; Mice, Transgenic ; Receptors, Cell Surface/analysis ; T-Lymphocytes, Cytotoxic/*immunology ; Viral Envelope Proteins/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
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    A (2000)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2000-08-19
    Description: A solid state, electronically addressable, bistable [2]catenane-based molecular switching device was fabricated from a single monolayer of the [2]catenane, anchored with phospholipid counterions, and sandwiched between an n-type polycrystalline silicon bottom electrode and a metallic top electrode. The device exhibits hysteretic (bistable) current/voltage characteristics. The switch is opened at +2 volts, closed at -2 volts, and read at approximately 0.1 volt and may be recycled many times under ambient conditions. A mechanochemical mechanism for the action of the switch is presented and shown to be consistent with temperature-dependent measurements of the device operation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collier -- Mattersteig -- Wong -- Luo -- Beverly -- Sampaio -- Raymo -- Stoddart -- Heath -- New York, N.Y. -- Science. 2000 Aug 18;289(5482):1172-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of California at Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095-1569, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10947980" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Electronically configurable molecular-based logic gates (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-20
    Description: Logic gates were fabricated from an array of configurable switches, each consisting of a monolayer of redox-active rotaxanes sandwiched between metal electrodes. The switches were read by monitoring current flow at reducing voltages. In the "closed" state, current flow was dominated by resonant tunneling through the electronic states of the molecules. The switches were irreversibly opened by applying an oxidizing voltage across the device. Several devices were configured together to produce AND and OR logic gates. The high and low current levels of those gates were separated by factors of 15 and 30, respectively, which is a significant enhancement over that expected for wired-logic gates.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Collier -- Wong -- Belohradsky -- Raymo -- Stoddart -- Kuekes -- Williams -- Heath -- New York, N.Y. -- Science. 1999 Jul 16;285(5426):391-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095-1569, USA. Hewlett-Packard Laboratories, Palo Alto, CA 94304-1392, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10411498" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    The C7 cluster: structure and infrared frequencies (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-24
    Description: Observation and characterization of the C7 cluster are reported. Carbon clusters are produced by laser vaporization of a graphite target followed by supersonic expansion of the vaporized material within a gas dynamically focused argon jet. Thirty-six sequential rovibrational lines of the nu 4 antisymmetric stretch fundamental of C7 are probed by gated detection of diode laser absorption. The observed spectrum is characteristic of a symmetrical linear molecule. Analysis of the spectrum indicates an effective average bond length of 1.2736(4) angstroms and a vibrational frequency of 2138.1951(10) reciprocal centimeters, in excellent agreement with ab initio calculations. This work will facilitate the astrophysical detection of this cluster.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heath, J R -- Sheeks, R A -- Cooksy, A L -- Saykally, R J -- New York, N.Y. -- Science. 1990 Aug 24;249:895-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California, Berkeley 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11538081" target="_blank"〉PubMed〈/a〉
    Keywords: Argon ; Astronomy/instrumentation/*methods ; Carbon/*analysis/*chemistry ; Lasers ; *Solar System ; Spectrophotometry, Infrared ; Spectrum Analysis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Tunable far-IR laser spectroscopy of jet-cooled carbon clusters: the nu 2 bending vibration of C3 (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-24
    Description: Seven rovibrational transitions of the (01(1)0) 〈-- (00(0)0) fundamental bending band of C3 have been measured with high precision with the use of a tunable far-infrared laser spectrometer. The C3 molecules were produced by laser vaporization of a graphite rod and cooled in a supersonic expansion. The astrophysically important nu 2 fundamental frequency is determined to be 63.416529(40) cm-1. These measurements provide the basis for studies of C3 in the interstellar medium with far-infrared astronomy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schmuttenmaer, C A -- Cohen, R C -- Pugliano, N -- Heath, J R -- Cooksy, A L -- Busarow, K L -- Saykally, R J -- New York, N.Y. -- Science. 1990 Aug 24;249:897-900.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California, Berkeley 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11538082" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomy/instrumentation/*methods ; Carbon/*analysis/chemistry ; Lasers ; *Solar System ; Spectrophotometry, Infrared ; Spectrum Analysis
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Sexual role reversal in mate-finding strategies of the cabbage looper moth (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-31
    Description: The mate-finding behavior of the cabbage looper moth Trichoplusia ni (Lepidoptera: Noctuidae) includes both female- and male-produced sex pheromones used in distinct mate-finding strategies. Both sexes release multicomponent pheromones attractive to the opposite sex. Male pheromone is comprised of d-linalool, m-cresol, and p-cresol released from abdominal hair pencils. Males exposed to host plant odor or to the female sex pheromone (Z)-7-dodecen-1-ol acetate are more attractive to females, suggesting stimulation of male pheromone release.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Landolt, P J -- Heath, R R -- New York, N.Y. -- Science. 1990 Aug 31;249(4972):1026-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17789611" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Diode-laser absorption spectroscopy of supersonic carbon cluster beams: the nu 3 spectrum of C5 (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-05-05
    Description: A new spectroscopic experiment has been developed in which rovibrational transitions of supersonically cooled carbon clusters, which were produced by laser vaporization of graphite, have been measured by direct-absorption diode-laser spectroscopy. Thirty-six sequential rovibrational lines of the nu 3 band of the C5 carbon cluster have been measured with Doppler-limited resolution. The absorption spectrum is characteristic of a linear molecule with a center of symmetry. Least-squares analysis of the spectrum indicates an effective carbon-carbon bond length of 1.283 angstroms, in good agreement with ab initio quantum chemical calculations. This work confirms the detection of C5 in IRC + 10216 reported in the accompanying paper.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heath, J R -- Cooksy, A L -- Gruebele, M H -- Schmuttenmaer, C A -- Saykally, R J -- New York, N.Y. -- Science. 1989 May 5;244:564-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, University of California, Berkeley 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11539817" target="_blank"〉PubMed〈/a〉
    Keywords: Astronomical Phenomena ; Astronomy ; Carbon/*analysis/chemistry ; *Lasers ; Quantum Theory ; Solar System ; Spectrum Analysis/*methods
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    A liquid-solution-phase synthesis of crystalline silicon (1992)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 1992-11-13
    Description: A liquid-solution-phase technique for preparing submicrometer-sized silicon single crystals is presented. The synthesis is based on the reduction of SiCl(4) and RSiCl(3) (R = H, octyl) by sodium metal in a nonpolar organic solvent at high temperatures (385 degrees C) and high pressures (〉 100 atmospheres). For R = H, the synthesis produces hexagonal-shaped silicon single crystals ranging from 5 to 3000 nanometers in size. For R = octyl, the synthesis also produces hexagonal-shaped silicon single crystals; however, the size range is controlled to 5.5 +/- 2.5 nanometers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heath, J R -- New York, N.Y. -- Science. 1992 Nov 13;258(5085):1131-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17789084" target="_blank"〉PubMed〈/a〉
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  • 9
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    Comment on "A global map of human impact on marine ecosystems" (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-09-13
    Description: Halpern et al. (Reports, 15 February 2008, p. 948) integrated spatial data on 17 drivers of change in the oceans to map the global distribution of human impact. Although fishery catches are a dominant driver, the data reflect activity while impacts occur at different space and time scales. Failure to account for this spatial disconnection could lead to potentially misleading conclusions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heath, Michael R -- New York, N.Y. -- Science. 2008 Sep 12;321(5895):1446; author reply 1446. doi: 10.1126/science.1157390.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Fisheries Research Services, Marine Laboratory, 375 Victoria Road, Aberdeen AB11 9DB, UK. heathmr@marlab.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18787153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Ecosystem ; *Fisheries ; *Fishes ; Food Chain ; *Human Activities ; Humans ; Oceans and Seas ; Population Dynamics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Graphene visualizes the first water adlayers on mica at ambient conditions (2010)
    American Association for the Advancement of Science (AAAS)
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    Publication Date: 2010-09-04
    Description: The dynamic nature of the first water adlayers on solid surfaces at room temperature has made the direct detection of their microscopic structure challenging. We used graphene as an atomically flat coating for atomic force microscopy to determine the structure of the water adlayers on mica at room temperature as a function of relative humidity. Water adlayers grew epitaxially on the mica substrate in a layer-by-layer fashion. Submonolayers form atomically flat, faceted islands of height 0.37 +/- 0.02 nanometers, in agreement with the height of a monolayer of ice. The second adlayers, observed at higher relative humidity, also appear icelike, and thicker layers appear liquidlike. Our results also indicate nanometer-scale surface defects serve as nucleation centers for the formation of both the first and the second adlayers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Xu, Ke -- Cao, Peigen -- Heath, James R -- New York, N.Y. -- Science. 2010 Sep 3;329(5996):1188-91. doi: 10.1126/science.1192907.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Kavli Nanoscience Institute and Division of Chemistry and Chemical Engineering, California Institute of Technology, MC 127-72, Pasadena, CA 91125, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20813950" target="_blank"〉PubMed〈/a〉
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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