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  • 1
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    Cleavage of Scarecrow-like mRNA targets directed by a class of Arabidopsis miRNA (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-21
    Description: Micro-RNAs (miRNAs) are regulatory molecules that mediate effects by interacting with messenger RNA (mRNA) targets. Here we show that Arabidopsis thaliana miRNA 39 (also known as miR171), a 21-ribonucleotide species that accumulates predominantly in inflorescence tissues, is produced from an intergenic region in chromosome III and functionally interacts with mRNA targets encoding several members of the Scarecrow-like (SCL) family of putative transcription factors. miRNA 39 is complementary to an internal region of three SCL mRNAs. The interaction results in specific cleavage of target mRNA within the region of complementarity, indicating that this class of miRNA functions like small interfering RNA associated with RNA silencing to guide sequence-specific cleavage in a developmentally controlled manner.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Llave, Cesar -- Xie, Zhixin -- Kasschau, Kristin D -- Carrington, James C -- AI27832/AI/NIAID NIH HHS/ -- AI43288/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):2053-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Gene Research and Biotechnology, and Department of Botany and Plant Pathology, Oregon State University, Corvallis, OR 97331, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242443" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/*genetics/metabolism ; Arabidopsis Proteins/*genetics/metabolism ; Base Pair Mismatch ; Base Sequence ; DNA, Intergenic ; Gene Silencing ; MicroRNAs ; Plant Leaves/genetics/metabolism ; Plant Stems/genetics/metabolism ; Plant Structures/genetics/metabolism ; RNA, Antisense/genetics/*metabolism ; RNA, Messenger/genetics/*metabolism ; RNA, Plant/genetics/metabolism ; RNA, Small Interfering ; RNA, Untranslated/genetics/*metabolism ; Transcription Factors/*genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Hierarchical action and inhibition of plant Dicer-like proteins in antiviral defense (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-06-03
    Description: The mechanisms underlying induction and suppression of RNA silencing in the ongoing plant-virus arms race are poorly understood. We show here that virus-derived small RNAs produced by Arabidopsis Dicer-like 4 (DCL4) program an effector complex conferring antiviral immunity. Inhibition of DCL4 by a viral-encoded suppressor revealed the subordinate antiviral activity of DCL2. Accordingly, inactivating both DCL2 and DCL4 was necessary and sufficient to restore systemic infection of a suppressor-deficient virus. The effects of DCL2 were overcome by increasing viral dosage in inoculated leaves, but this could not surmount additional, non-cell autonomous effects of DCL4 specifically preventing viral unloading from the vasculature. These findings define a molecular framework for studying antiviral silencing and defense in plants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deleris, Angelique -- Gallego-Bartolome, Javier -- Bao, Jinsong -- Kasschau, Kristin D -- Carrington, James C -- Voinnet, Olivier -- AI43288/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2006 Jul 7;313(5783):68-71. Epub 2006 Jun 1.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut de Biologie Moleculaire des Plantes, CNRS Unite Propre de Recherche (UPR) 2357, 12, rue du General Zimmer, 67084 Strasbourg Cedex, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16741077" target="_blank"〉PubMed〈/a〉
    Keywords: Arabidopsis/enzymology/genetics/metabolism/*virology ; Arabidopsis Proteins/antagonists & inhibitors/genetics/*metabolism ; Carmovirus/physiology ; Cell Cycle Proteins/antagonists & inhibitors/genetics/*metabolism ; Green Fluorescent Proteins/metabolism ; Mutation ; Plant Diseases/virology ; Plant Leaves/virology ; Plant Viruses/*physiology ; Plants, Genetically Modified ; *RNA Interference ; RNA Viruses/physiology ; RNA, Double-Stranded/metabolism ; RNA, Small Interfering/*metabolism ; RNA, Viral/*metabolism ; RNA-Induced Silencing Complex/metabolism ; Recombinant Fusion Proteins/metabolism ; Ribonuclease III/antagonists & inhibitors/genetics/*metabolism ; Ribonucleases/antagonists & inhibitors/genetics/*metabolism ; Signal Transduction ; Viral Proteins/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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    PAPER CURRENT
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