Publication Date:
1987-08-07
Description:
Trisomy 21 usually results from nondisjunction during meiosis I. In order to determine whether nondisjunction results from failure of normal chromosome pairing or premature unpairing, recombination frequencies were estimated between DNA polymorphic markers on the long arm of chromosome 21 in families containing one individual with trisomy 21. The recombination frequencies on chromosomes 21 that had undergone nondisjunction were then compared to those on chromosomes 21 that had disjoined normally. The data indicate that recombination is reduced between DNA markers on nondisjoined chromosomes 21. These results are consistent with the hypothesis that reduced chiasma formation predisposes to nondisjunction, resulting in trisomy 21 in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Warren, A C -- Chakravarti, A -- Wong, C -- Slaugenhaupt, S A -- Halloran, S L -- Watkins, P C -- Metaxotou, C -- Antonarakis, S E -- GM07814/GM/NIGMS NIH HHS/ -- GM33771/GM/NIGMS NIH HHS/ -- HD19491/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1987 Aug 7;237(4815):652-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2955519" target="_blank"〉PubMed〈/a〉
Keywords:
Chromosome Mapping
;
*Chromosomes, Human, Pair 21
;
Down Syndrome/*genetics
;
Genetic Linkage
;
Genetic Markers
;
Humans
;
*Nondisjunction, Genetic
;
*Recombination, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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