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  • Cues  (3)
  • American Association for the Advancement of Science (AAAS)  (3)
  • Blackwell Publishing Ltd
  • 1
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    Neuronal correlates of goal-based motor selection in the prefrontal cortex (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-07-12
    Description: Choosing an action that leads to a desired goal requires an understanding of the linkages between actions and their outcomes. We investigated neural mechanisms of such goal-based action selection. We trained monkeys on a task in which the relation between visual cues, action types, and reward conditions changed regularly, such that the monkeys selected their actions based on anticipated reward conditions. A significant number of neurons in the medial prefrontal cortex were activated, after cue presentation and before motor execution, only by particular action-reward combinations. This prefrontal activity is likely to underlie goal-based action selection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsumoto, Kenji -- Suzuki, Wataru -- Tanaka, Keiji -- New York, N.Y. -- Science. 2003 Jul 11;301(5630):229-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan. matsumot@postman.riken.go.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12855813" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Analysis of Variance ; Animals ; Brain Mapping ; Conditioning (Psychology) ; Cues ; Decision Making ; *Goals ; Haplorhini ; *Learning ; Memory/physiology ; Neurons/*physiology ; Prefrontal Cortex/*physiology ; Psychomotor Performance ; *Reward
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Neuroscience. Conflict and cognitive control (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-02-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsumoto, Kenji -- Tanaka, Keiji -- New York, N.Y. -- Science. 2004 Feb 13;303(5660):969-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan. matsumot@riken.jp〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14963319" target="_blank"〉PubMed〈/a〉
    Keywords: Brain Mapping ; *Cognition ; *Conflict (Psychology) ; Cues ; Frontal Lobe/*physiology ; Gyrus Cinguli/*physiology ; Humans ; Magnetic Resonance Imaging ; Neurons/physiology ; Neuropsychological Tests ; Prefrontal Cortex/*physiology ; Reaction Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-07-04
    Description: Much of our behavior is guided by rules. Although human prefrontal cortex (PFC) and anterior cingulate cortex (ACC) are implicated in implementing rule-guided behavior, the crucial contributions made by different regions within these areas are not yet specified. In an attempt to bridge human neuropsychology and nonhuman primate neurophysiology, we report the effects of circumscribed lesions to macaque orbitofrontal cortex (OFC), principal sulcus (PS), superior dorsolateral PFC, ventrolateral PFC, or ACC sulcus, on separable cognitive components of a Wisconsin Card Sorting Test (WCST) analog. Only the PS lesions impaired maintenance of abstract rules in working memory; only the OFC lesions impaired rapid reward-based updating of representations of rule value; the ACC sulcus lesions impaired active reference to the value of recent choice-outcomes during rule-based decision-making.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Buckley, Mark J -- Mansouri, Farshad A -- Hoda, Hassan -- Mahboubi, Majid -- Browning, Philip G F -- Kwok, Sze C -- Phillips, Adam -- Tanaka, Keiji -- G0300817/Medical Research Council/United Kingdom -- Medical Research Council/United Kingdom -- New York, N.Y. -- Science. 2009 Jul 3;325(5936):52-8. doi: 10.1126/science.1172377.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford, OX1 3UD, UK. buckley@psy.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19574382" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Behavior, Animal ; Brain Mapping ; Cues ; *Decision Making ; Frontal Lobe/physiology ; *Learning ; Macaca ; Macaca mulatta ; Memory, Short-Term ; Neurons/physiology ; Neuropsychological Tests ; Prefrontal Cortex/*physiology ; Reinforcement (Psychology) ; Reward
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
    Location Call Number Expected Availability
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