ISSN:
1432-0983
Keywords:
Galactose fermentation
;
Saccharomyces cerevisiae
;
Regulatory mutant
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary A novel type of regulatory mutation for galactose metabolism in Saccharomyces cerevisiae is described. The mutation named gal11 was recessive, non-allelic to GAL4, GAL80, GAL2, or GAL3, and unlinked to the gene cluster of GAL1, GAL10, and GAL7. It caused a ‘coordinate’ reduction of galactokinase, galactose-1-P uridylyl transferase, and UDP-glucose 4-epimerase by a factor of more than 5, rendering the mutant cells galactose-nonfermenting. The effect of the mutation was manifested not only in cells grown on galactose but also in cells constitutively synthesizing the galactose-metabolizing enzymes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00420623
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