Publication Date:
1993-06-25
Description:
Nitric oxide (NO) and carbon monoxide (CO) may act as retrograde messages for long-term potentiation (LTP) in the hippocampus. Zinc protoporphyrin IX, an inhibitor of the enzyme that produces CO, blocked induction of LTP in the CA1 region of hippocampal slices. Application of either NO or CO to slices produced a rapid and long-lasting increase in the size of evoked synaptic potentials if, and only if, the application occurred at the same time as weak tetanic stimulation. This long-term enhancement was spatially restricted to synapses from active presynaptic fibers and appeared to involve mechanisms utilized by LTP, occluding the subsequent induction of LTP by strong tetanic stimulation. The enhancement by NO and CO was not blocked by an N-methyl-D-aspartate (NMDA) receptor blocker, suggesting that NO and CO act downstream from the NMDA receptor. Also, CO produced long-term enhancement when paired with low-frequency stimulation. These results are consistent with the hypothesis that NO and CO, either alone or in combination, serve as retrograde messages that produce activity-dependent presynaptic enhancement during LTP.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhuo, M -- Small, S A -- Kandel, E R -- Hawkins, R D -- AG08702/AG/NIA NIH HHS/ -- MH45923/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1993 Jun 25;260(5116):1946-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, NY.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8100368" target="_blank"〉PubMed〈/a〉
Keywords:
6-Cyano-7-nitroquinoxaline-2,3-dione
;
Animals
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Carbon Monoxide/*pharmacology
;
Electric Stimulation
;
Guinea Pigs
;
Hippocampus/drug effects/*physiology
;
In Vitro Techniques
;
Male
;
Membrane Potentials/drug effects
;
Nitric Oxide/*pharmacology
;
Protoporphyrins/pharmacology
;
Quinoxalines/pharmacology
;
Signal Transduction/drug effects
;
Synapses/drug effects/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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