Publication Date:
1997-02-14
Description:
Putative endothelial cell (EC) progenitors or angioblasts were isolated from human peripheral blood by magnetic bead selection on the basis of cell surface antigen expression. In vitro, these cells differentiated into ECs. In animal models of ischemia, heterologous, homologous, and autologous EC progenitors incorporated into sites of active angiogenesis. These findings suggest that EC progenitors may be useful for augmenting collateral vessel growth to ischemic tissues (therapeutic angiogenesis) and for delivering anti- or pro-angiogenic agents, respectively, to sites of pathologic or utilitarian angiogenesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Asahara, T -- Murohara, T -- Sullivan, A -- Silver, M -- van der Zee, R -- Li, T -- Witzenbichler, B -- Schatteman, G -- Isner, J M -- 2824/PHS HHS/ -- 53354/PHS HHS/ -- 57516/PHS HHS/ -- New York, N.Y. -- Science. 1997 Feb 14;275(5302):964-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine (Cardiology), St. Elizabeth's Medical Center, Tufts University School of Medicine, 736 Cambridge Street, Boston, MA 02135, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9020076" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD34/analysis
;
Biomarkers/analysis
;
Cell Differentiation
;
Cell Separation
;
Cells, Cultured
;
Endothelium, Vascular/chemistry/*cytology
;
Flow Cytometry
;
Hindlimb/blood supply
;
Humans
;
Ischemia/physiopathology
;
Mice
;
Mice, Inbred C57BL
;
Mice, Nude
;
Mice, Transgenic
;
*Neovascularization, Physiologic
;
Nitric Oxide Synthase/analysis
;
Rabbits
;
Receptor Protein-Tyrosine Kinases/analysis
;
Receptors, Growth Factor/analysis
;
Receptors, Vascular Endothelial Growth Factor
;
Stem Cells/chemistry/*cytology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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