Publication Date:
1995-04-21
Description:
Infection by human immunodeficiency virus-type 1 (HIV-1) is typified by the progressive depletion of CD4 T lymphocytes and deterioration of immune function in most patients. A central unresolved issue in acquired immunodeficiency syndrome (AIDS) pathogenesis is the mechanism underlying this T cell depletion. HIV-1 Tat protein was shown to induce cell death by apoptosis in a T cell line and in cultured peripheral blood mononuclear cells from uninfected donors. This Tat-induced apoptosis was inhibitable by growth factors and was associated with enhanced activation of cyclin-dependent kinases.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, C J -- Friedman, D J -- Wang, C -- Metelev, V -- Pardee, A B -- AI-35511/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1995 Apr 21;268(5209):429-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Cell Growth and Regulation, Dana-Farber Cancer Institute, Boston, MA, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7716549" target="_blank"〉PubMed〈/a〉
Keywords:
*Apoptosis
;
Base Sequence
;
*CDC2-CDC28 Kinases
;
Cyclin-Dependent Kinase 2
;
Cyclin-Dependent Kinases/metabolism
;
Enzyme Activation
;
Gene Products, tat/pharmacology/*physiology
;
Genes, tat
;
*Hiv-1
;
Humans
;
Leukocytes, Mononuclear/*cytology/enzymology
;
Molecular Sequence Data
;
Protein-Serine-Threonine Kinases/metabolism
;
Recombinant Proteins/pharmacology
;
T-Lymphocytes/*cytology/enzymology
;
Transfection
;
Tumor Cells, Cultured
;
tat Gene Products, Human Immunodeficiency Virus
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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