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  • 2000-2004  (69)
  • 1975-1979  (111)
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  • 1
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    Seismic images of crust and upper mantle beneath Tibet: evidence for Eurasian plate subduction (2002)
    In:  Science, Jena, Physica-Verlag, vol. 298, no. 5596, pp. 1219-1221, pp. L24313, (ISSN: 1340-4202)
    Details
    Publication Date: 2002
    Keywords: Seismology ; China ; Plate tectonics ; Subduction zone ; Receiver functions
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    BIBLIOGRAPHY SEISMOLOGY
  • 2
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    Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-12-12
    Description: Nasopharyngeal carriage is the major reservoir for Streptococcus pneumoniae in the community. Although eliminating this reservoir would greatly reduce disease occurrence, no suitable intervention has been available for this purpose. We show here that seconds after contact, a purified pneumococcal bacteriophage lytic enzyme (Pal) is able to kill 15 common serotypes of pneumococci, including highly penicillin-resistant strains. In vivo, previously colonized mice revealed undetectable pneumococcal titers 5 hours after a single enzyme treatment. Pal enzyme had little or no effect on microorganisms normally found in the human oropharynx, and Pal-resistant pneumococci could not be detected after extensive exposure to the enzyme.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loeffler, J M -- Nelson, D -- Fischetti, V A -- New York, N.Y. -- Science. 2001 Dec 7;294(5549):2170-2.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Bacterial Pathogenesis, The Rockefeller University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11739958" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Bacterial Capsules/physiology ; Bacteriolysis ; Cell Membrane/drug effects/ultrastructure ; Cell Wall/drug effects/ultrastructure ; Colony Count, Microbial ; Drug Resistance, Bacterial ; Humans ; Mice ; Mutation ; N-Acetylmuramoyl-L-alanine Amidase/*metabolism/*pharmacology ; Nasopharynx/*microbiology ; Random Allocation ; Streptococcus/drug effects/growth & development ; Streptococcus Phages/*enzymology ; Streptococcus pneumoniae/*drug effects/growth & ; development/physiology/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    Detection of widespread fluids in the Tibetan crust by magnetotelluric studies (2001)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2001-04-28
    Description: Magnetotelluric exploration has shown that the middle and lower crust is anomalously conductive across most of the north-to-south width of the Tibetan plateau. The integrated conductivity (conductance) of the Tibetan crust ranges from 3000 to greater than 20,000 siemens. In contrast, stable continental regions typically exhibit conductances from 20 to 1000 siemens, averaging 100 siemens. Such pervasively high conductance suggests that partial melt and/or aqueous fluids are widespread within the Tibetan crust. In southern Tibet, the high-conductivity layer is at a depth of 15 to 20 kilometers and is probably due to partial melt and aqueous fluids in the crust. In northern Tibet, the conductive layer is at 30 to 40 kilometers and is due to partial melting. Zones of fluid may represent weaker areas that could accommodate deformation and lower crustal flow.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wei, W -- Unsworth, M -- Jones, A -- Booker, J -- Tan, H -- Nelson, D -- Chen, L -- Li, S -- Solon, K -- Bedrosian, P -- Jin, S -- Deng, M -- Ledo, J -- Kay, D -- Roberts, B -- New York, N.Y. -- Science. 2001 Apr 27;292(5517):716-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Geophysics, China University of Geosciences, Beijing, People's Republic of China.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11326096" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Cyclic variation and solar forcing of Holocene climate in the Alaskan subarctic (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-09-27
    Description: High-resolution analyses of lake sediment from southwestern Alaska reveal cyclic variations in climate and ecosystems during the Holocene. These variations occurred with periodicities similar to those of solar activity and appear to be coherent with time series of the cosmogenic nuclides 14C and 10Be as well as North Atlantic drift ice. Our results imply that small variations in solar irradiance induced pronounced cyclic changes in northern high-latitude environments. They also provide evidence that centennial-scale shifts in the Holocene climate were similar between the subpolar regions of the North Atlantic and North Pacific, possibly because of Sun-ocean-climate linkages.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hu, Feng Sheng -- Kaufman, Darrell -- Yoneji, Sumiko -- Nelson, David -- Shemesh, Aldo -- Huang, Yongsong -- Tian, Jian -- Bond, Gerard -- Clegg, Benjamin -- Brown, Thomas -- New York, N.Y. -- Science. 2003 Sep 26;301(5641):1890-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Plant Biology, University of Illinois, Urbana, IL 61801, USA. fshu@life.uiuc.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14512624" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Odd-parity superconductivity in Sr2RuO4 (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-11-13
    Description: Phase-sensitive measurements were made on Sr2RuO4 to establish unambiguously the odd-parity pairing in this material. The critical current of Au(0.5)In(0.5)-Sr2RuO4 superconducting quantum interference devices prepared on Sr2RuO4 single crystals was found to be a maximum for devices with junctions on the same side of the crystal and a minimum for devices with junctions on opposite sides, in the limit of zero magnetic flux; these findings indicate that the phase of the superconducting order parameter in Sr2RuO4 changes by pi under inversion. This result verifies the odd-parity pairing symmetry and the formation of spin-triplet Cooper pairs in Sr2RuO4.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nelson, K D -- Mao, Z Q -- Maeno, Y -- Liu, Y -- New York, N.Y. -- Science. 2004 Nov 12;306(5699):1151-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Pennsylvania State University, University Park, PA 16802, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15539595" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2 (2004)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2004-12-25
    Description: Binding of Sonic Hedgehog (Shh) to Patched (Ptc) relieves the latter's tonic inhibition of Smoothened (Smo), a receptor that spans the cell membrane seven times. This initiates signaling which, by unknown mechanisms, regulates vertebrate developmental processes. We find that two molecules interact with mammalian Smo in an activation-dependent manner: G protein-coupled receptor kinase 2 (GRK2) leads to phosphorylation of Smo, and beta-arrestin 2 fused to green fluorescent protein interacts with Smo. These two processes promote endocytosis of Smo in clathrin-coated pits. Ptc inhibits association of beta-arrestin 2 with Smo, and this inhibition is relieved in cells treated with Shh. A Smo agonist stimulated and a Smo antagonist (cyclopamine) inhibited both phosphorylation of Smo by GRK2 and interaction of beta-arrestin 2 with Smo. beta-Arrestin 2 and GRK2 are thus potential mediators of signaling by activated Smo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Wei -- Ren, Xiu-Rong -- Nelson, Christopher D -- Barak, Larry S -- Chen, James K -- Beachy, Philip A -- de Sauvage, Frederic -- Lefkowitz, Robert J -- New York, N.Y. -- Science. 2004 Dec 24;306(5705):2257-60.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. w.chen@duke.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15618519" target="_blank"〉PubMed〈/a〉
    Keywords: Arrestins/*metabolism ; Cell Line ; Cell Membrane/*metabolism ; Clathrin/metabolism ; Coated Pits, Cell-Membrane/metabolism ; Cyclic AMP-Dependent Protein Kinases/*metabolism ; Cyclohexylamines/pharmacology ; Cytosol/metabolism ; Dynamins/metabolism ; Endocytosis ; Hedgehog Proteins ; Humans ; Membrane Proteins/metabolism ; Phosphorylation ; Receptors, Cell Surface ; Receptors, G-Protein-Coupled/*metabolism ; Recombinant Fusion Proteins/metabolism ; Signal Transduction ; Thiophenes/pharmacology ; Trans-Activators/metabolism ; Transfection ; Veratrum Alkaloids/pharmacology ; beta-Adrenergic Receptor Kinases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Seismic images of crust and upper mantle beneath Tibet: evidence for Eurasian plate subduction (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-11-09
    Description: Seismic data from central Tibet have been combined to image the subsurface structure and understand the evolution of the collision of India and Eurasia. The 410- and 660-kilometer mantle discontinuities are sharply defined, implying a lack of a subducting slab beneath the plateau. The discontinuities appear slightly deeper beneath northern Tibet, implying that the average temperature of the mantle above the transition zone is about 300 degrees C hotter in the north than in the south. There is a prominent south-dipping converter in the uppermost mantle beneath northern Tibet that might represent the top of the Eurasian mantle lithosphere underthrusting the northern margin of the plateau.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kind, R -- Yuan, X -- Saul, J -- Nelson, D -- Sobolev, S V -- Mechie, J -- Zhao, W -- Kosarev, G -- Ni, J -- Achauer, U -- Jiang, M -- New York, N.Y. -- Science. 2002 Nov 8;298(5596):1219-21.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉GeoForschungsZentrum Potsdam, Telegrafenberg, 14473 Potsdam, Germany. kind@gfz-potsdam.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12424374" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2003-09-06
    Description: beta-Arrestins bind to activated seven transmembrane-spanning (7TMS) receptors (G protein-coupled receptors) after the receptors are phosphorylated by G protein-coupled receptor kinases (GRKs), thereby regulating their signaling and internalization. Here, we demonstrate an unexpected and analogous role of beta-arrestin 2 (betaarr2) for the single transmembrane-spanning type III transforming growth factor-beta (TGF-beta) receptor (TbetaRIII, also referred to as betaglycan). Binding of betaarr2 to TbetaRIII was also triggered by phosphorylation of the receptor on its cytoplasmic domain (likely at threonine 841). However, such phosphorylation was mediated by the type II TGF-beta receptor (TbetaRII), which is itself a kinase, rather than by a GRK. Association with betaarr2 led to internalization of both receptors and down-regulation of TGF-beta signaling. Thus, the regulatory actions of beta-arrestins are broader than previously appreciated, extending to the TGF-beta receptor family as well.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chen, Wei -- Kirkbride, Kellye C -- How, Tam -- Nelson, Christopher D -- Mo, Jinyao -- Frederick, Joshua P -- Wang, Xiao-Fan -- Lefkowitz, Robert J -- Blobe, Gerard C -- CA 75368/CA/NCI NIH HHS/ -- CA 91816/CA/NCI NIH HHS/ -- HL 16037/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2003 Sep 5;301(5638):1394-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Duke University Medical Center, Departments of Medicine and Biochemistry, Durham, NC 27710, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12958365" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Motifs ; Amino Acid Sequence ; Animals ; Arrestins/genetics/*metabolism ; Cell Line ; Cell Membrane/metabolism ; Cytoplasm/metabolism ; Down-Regulation ; *Endocytosis ; Humans ; Keratinocytes/metabolism ; Mice ; Mice, Knockout ; Molecular Sequence Data ; Mutagenesis ; Phosphorylation ; Protein Structure, Tertiary ; Protein-Serine-Threonine Kinases ; Proteoglycans/chemistry/genetics/*metabolism ; RNA, Small Interfering ; Receptors, Transforming Growth Factor beta/chemistry/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; Transfection ; Transforming Growth Factor beta ; Transforming Growth Factor beta1
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    The influence of transport on industrial location choice: a stated preference experiment (2000)
    Elsevier
    Details
    Publication Date: 2000-09-01
    Print ISSN: 0965-8564
    Electronic ISSN: 1879-2375
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Elsevier
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  • 10
    Electronic Resource
    Electronic Resource
    Carbon-13 CIDNP from reactions of some simple organic and inorganic radicals during pulse radiolysis (1979)
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 83 (1979), S. 3444-3448 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/j100489a026
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    Paper (German National Licenses)
    Fulltext
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