ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
Despite systemic prophylaxis, infection rates after orthopedic surgery can reach morethan 1%. A new HAP/TCP bone substitute loaded with 125 mg of gentamicin was designed forprophylactic use. Its aim was to enhance the efficacy of systemic prophylactic treatments byincreasing the local antibiotic concentration. For prophylactic applications, release had to take placewithin 48 hours not to select antibiotic-resistant bacterial strains. The purpose of this study was toinvestigate the releasing mechanisms of gentamicin from the porous HAP/TCP matrix. The releaserate of gentamicin trough the porosities of the bone substitute was investigated in vitro, in 0.9%sodium chloride solution. The rate appeared to be related to the bone substitute volume and fitclassical diffusion laws. All the gentamicin was released in less than 48 hours: this rate correspondsto the recommendations for the prophylactic use of antibiotics
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1203.pdf
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