Publication Date:
2013-06-21
Description:
In the Drosophila optic lobes, the medulla processes visual information coming from inner photoreceptors R7 and R8 and from lamina neurons. It contains approximately 40,000 neurons belonging to more than 70 different types. Here we describe how precise temporal patterning of neural progenitors generates these different neural types. Five transcription factors-Homothorax, Eyeless, Sloppy paired, Dichaete and Tailless-are sequentially expressed in a temporal cascade in each of the medulla neuroblasts as they age. Loss of Eyeless, Sloppy paired or Dichaete blocks further progression of the temporal sequence. We provide evidence that this temporal sequence in neuroblasts, together with Notch-dependent binary fate choice, controls the diversification of the neuronal progeny. Although a temporal sequence of transcription factors had been identified in Drosophila embryonic neuroblasts, our work illustrates the generality of this strategy, with different sequences of transcription factors being used in different contexts.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701960/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701960/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Li, Xin -- Erclik, Ted -- Bertet, Claire -- Chen, Zhenqing -- Voutev, Roumen -- Venkatesh, Srinidhi -- Morante, Javier -- Celik, Arzu -- Desplan, Claude -- GM058575/GM/NIGMS NIH HHS/ -- R01 EY017916/EY/NEI NIH HHS/ -- Canadian Institutes of Health Research/Canada -- England -- Nature. 2013 Jun 27;498(7455):456-62. doi: 10.1038/nature12319. Epub 2013 Jun 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, New York University, 100 Washington Square East, New York, New York 10003, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23783517" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/*cytology/growth & development
;
*Cell Differentiation
;
*Cell Lineage
;
Drosophila Proteins/metabolism
;
Drosophila melanogaster/anatomy & histology/*cytology/metabolism
;
Female
;
Gene Expression Regulation
;
Male
;
Neural Stem Cells/*cytology/metabolism
;
Neurons/*cytology/*metabolism
;
Time Factors
;
Transcription Factors/metabolism
;
Visual Pathways/cytology
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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