Publication Date:
2015-07-04
Description:
Article Sirtuins are NAD + -dependent deacylases implicated in the regulation of stress responses, bioenergetics and epigenetic control. Here the authors describe the crystal structure of a sirtuin-activating compounds (STAC)-sirtuin complex and begin to elucidate the mechanism of sirtuins activation by STACs. Nature Communications doi: 10.1038/ncomms8645 Authors: Han Dai, April W. Case, Thomas V. Riera, Thomas Considine, Jessica E. Lee, Yoshitomo Hamuro, Huizhen Zhao, Yong Jiang, Sharon M. Sweitzer, Beth Pietrak, Benjamin Schwartz, Charles A. Blum, Jeremy S. Disch, Richard Caldwell, Bruce Szczepankiewicz, Christopher Oalmann, Pui Yee Ng, Brian H. White, Rebecca Casaubon, Radha Narayan, Karsten Koppetsch, Francis Bourbonais, Bo Wu, Junfeng Wang, Dongming Qian, Fan Jiang, Cheney Mao, Minghui Wang, Erding Hu, Joe C. Wu, Robert B. Perni, George P. Vlasuk, James L. Ellis
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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